Recent advances in pathogenesis and treatment of classical Philadelphia-negative myeloproliferative neoplasms
Journal Title: Postępy Nauk Medycznych - Year 2011, Vol 24, Issue 6
Abstract
In the last few years we have witnessed a great progress in our understanding of the pathogenesis of myeloproliferative neoplasms (MPNs). The classical Philadelphia-negative MPNs include polycythemia vera (PV), essential thrombocythemia (ET) and primary myelofibrosis (PMF). They were grouped together based on similar clinical phenotype by Dameshek in 1951. Since then the identification of JAK2V617F and MPL mutations has changed our view on disease pathogenesis and led to the revision of World Health Organization (WHO) diagnostic criteria for classical Philadelphia-negative MPNs. A new classification issued in 2008 incorporated these molecular abnormalities and therefore has modified the diagnostic approach. Moreover, these mutations have modified the strategies for monitoring and response assessment and they could become the potential targets for small-molecule agents. In this review we present current overview on molecular basis of MPNs including novel mutations and discuss the diagnostic criteria and therapeutic modalities.
Authors and Affiliations
Grzegorz Helbig, Sławomira Kyrcz-Krzemień
Keywords
Related Articles
- EP ID EP54209
- DOI -
- Views 115
- Downloads 0
Znaczenie kliniczne hyperhomocysteinemii u chorych z udarem niedokrwiennym mózgu
<b>Wstęp. </b>Homocysteina jest aminokwasem powstającym w czasie metabolizmu metioniny do cysteiny. Podwyższony poziom homocysteiny jest niezależnym czynnikiem ryzyka dla chorób układu sercowo...
Acute poisoning as a cause of hospitalization of children and adolescents in the pediatric ward – 9-year analysis
Introduction. Among the reasons of hospital treatment of children and adolescents poisonings play a significant role, both accidental and intentional as a result of a suicide attempt.The aim of the study is to assess the...
Age-related macular degeneration (AMD) – disease of ageing society
Age-related macular degeneration is the leading cause of blindness in elderly population. About 25 millions of individuals are affected with AMD. The most consistent risk factors associated with this ocular condition are...
Zasady farmakoterapii w wieku podeszłym
Geriatria jest dziedziną związaną z „polisymptomatologią” i wielolekowością, a racjonalne podejście do farmakoterapii osób starszych jest jednym z najistotniejszych aspektów sprawowanej nad nimi opieki lekarskiej. Znajom...
Contrast-induced nephropathy (CIN)
The rapid development of percutaneuos coronarography and vascular interventional technologies has led to a dramatic increase in the number of patients receiving contrast media with which might lead to acute kidney injury...