RECENT DEVELOPMENTS AND MULTIPLE BIOLOGICAL ACTIVITIES AVAILABLE WITH 1, 8-NAPHTHYRIDINE DERIVATIVES: A REVIEW
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2019, Vol 11, Issue 1
Abstract
Within the wide range of nitrogen-containing heterocyclic compounds, the derivatives of 1,8-naphthyridine (NPTR) have gained a rising interest due to their reported versatile biological activities. The derivatives of NPTR scaffold are found to invite special interest from researchers nowadays on the significance of their manifestations of multiple attractive pharmacological activities which establish them as an effective and versatile tool in pharmaceutical chemistry and drug discovery. The diverse biological activities mainly include anti-inflammatory, antimicrobial, antiviral, anticancer, antihypertensive and analgesic activities. Novel NPTR scaffold has emerged its potency to treat neurological diseases like depression and Alzheimer's disease. Further these agents possess different inhibitory activities, such as anti-HIV, anti-osteoporotic, αvβ3 antagonism, antimalarial, platelet aggregation, anti-oxidant, anti-allergic, gastric antisecretory, anticonvulsant, epidermal growth factor receptor (EGFR) inhibition, protein kinase inhibition, ionotropic properties, β3 antagonism, phosphodiesterase 4 (PDE 4) inhibitions, adenosine receptor agonistic activity, adrenoceptors antagonism and DNA stabilizing activity, etc. In this review, we highlight the updates of different 1,8-naphthyridine derivatives and explain the key data available in the context of various biological activities of NPTR derivatives available from the literature. This may direct opportunity in researches in the synthesis of novel medicinal agents and the development of new heterocycles for modification of existing biological actions as well as evaluation of other possible pharmacological activities.
Authors and Affiliations
Vinod Kumar Gurjar, Dilipkumar Pal
Keywords
Related Articles
- EP ID EP566060
- DOI 10.22159/ijpps.2019v11i1.30429
- Views 77
- Downloads 0
FORMULATION, EVALUATION AND SOLID-STATE THERMOGRAPHIC CHARACTERIZATION OF CFC FREE BECLOMETASONE DIPROPIONATE PRESSURIZED METERED DOSE INHALATION
Objective: In view of the aim, the objective of the present work was to develop a solution based pulmonary drug delivery system containing Beclometasone dipropionate 250mcg using a Hydrofluoroalkane (HFA 134a and HFA 227...
IMPACT OF tAI IN TRANSLATIONAL DYNAMICS OF HOMO SAPIENS GENES IN ESCHERICHIA COLI GENOME
Objective: Translation of mRNA to protein is a central biological process, and its regulation is vital for cell growth, development and differentiation. It is known that the tRNA molecules play a role of nearly 40% in th...
EVALUATION OF HEPATOPROTECTIVE ACTIVITY OF STEM EXTRACTS OF CUSCUTA REFLEXA (ROXB) IN RATS
Objective: Cuscuta Reflexa (Convolvulaceae) is a plant with a variety of ethnic medicinal uses along with antioxidant activity. Hence it was planned to evaluate the hepatoprotective activity with alcoholic extracts of st...
SYNTHESIS, SPECTRAL CHARACTERIZATION AND ANTIMICROBIAL ACTIVITY OF NOVEL 2-HYDRAZONO-2(3H)-THIAZOLE DERIVATIVES DERIVED FROM 4-(3-CHLOROPHENYL)-3-THIOSEMICARBAZIDE
Objective: A series of substituted 2-hydrazono-2(3H)-thiazole derivatives were synthesized from 4-(3-chlorophenyl)-3-thiosemicarbazide and evaluated in vitro for antimicrobial activity against Escherichia coli, Candida a...
ANTIBACTERIAL ACTIVITY OF PLANT BIOSURFACTANT EXTRACT FROM SAPINDUS MUKOROSSI AND IN SILICO EVALUATION OF ITS BIOACTIVITY
Objective: Natural biosurfactants can replace synthetic surfactants and find applications in cosmetic products. Saponin extracts from Sapindus mukorossi fruits have emulsifying properties and have traditionally been used...