RECENT TRENDS IN POSITIVE AND NEGATIVE ASPECTS OF FOOD ON BIOAVALABILTY OF DRUGS
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2013, Vol 1, Issue 3
Abstract
The therapeutic effectiveness of a drug depends upon the ability of the dosage form to deliver the medicament to its site of action at a rate & amount sufficient to produce the desired pharmacologic response. This attribute of the dosage form is referred to as Physiologic availability or Biologic availability or simply availability. For most of the drugs, the pharmacologic response is directly related to the plasma levels. Thus, the term, Bioavailability is defined as the rate & extent (amount) of absorption of unchanged drug from its dosage form. Bioavailability refers to the difference between the amounts of a substance, such as a drug, herb, or chemical, to which a person is exposed and the actual dose of the substance the body receives. Bioavailability accounts for the difference between exposure and dose. A drug's therapeutic action or a chemical's toxicity is determined by the dose received at the target site in the body. The dose at the target site is determined by the amount of the substance absorbed by the body, which depends on its bioavailability. If a substance is ingested, for example, its bioavailability is determined by the amount that is absorbed by the intestinal tract. If a substance is inhaled, its bioavailability is determined by the amount that is absorbed by the lungs. Understanding bioavailability is critical to determining the amount of a drug to administer or the level of chemical exposure that is likely to produce toxicity.
Authors and Affiliations
Gowthami B Sk Nahida Fazilath Sanaulla Md K Prudhvi Raj Dastagiriah G Tabassum Sk
Keywords
Related Articles
- EP ID EP33057
- DOI -
- Views 361
- Downloads 0
FORMULATION AND E VALUATION OF FAMOTIDINE FAST DISSOLVING TABLETS BY DIRECT COMPRESSION METHOD
Fast dissolving tablets were highly accepted drug delivery system. Fast dissolving tablets were dissolved/ disintegrated in the mouth within a matter of few seconds without need of water. The aim of the present study wa...
Prevalence of refractive errors among dental students
Introduction: Prevalence of refractive errors among students pursuing higher studies is very high. Very little data about the prevalence of refractive errors among dental students in India is available. The present stu...
TRANSDERMAL IONTOPHORESIS TECHNIQUE-A POTENTIAL EMERGING DRUG DELIVERY SYSTEM
The objective of delivery system is to achieve optimum therapeutic management. But, it still remains a challenge in the field of pharmaceuticals for delivery of ionic species such as proteins and peptides. Development...
A STUDY ON ROLE OF DEMOGRAPHIC FACTORS IN SMALL INVESTORS’ SAVINGS IN STOCK MARKET
Stock market helps to channelize household savings to the corporate sector which in turn utilize for the development of industrial and service sector. An equity share is a part of the ownership capital of a company and...
SUSTAINED RELEASE DRUG DELIVERY SYSTEM
The oral route is the most popular route used for administration of drugs, which is due in part to the ease of administration and to the fact that gastrointestinal physiology offers more flexibility in dosage form desi...