TRANSDERMAL IONTOPHORESIS TECHNIQUE-A POTENTIAL EMERGING DRUG DELIVERY SYSTEM
Journal Title: Indian Journal of Research in Pharmacy and Biotechnology - Year 2013, Vol 1, Issue 1
Abstract
The objective of delivery system is to achieve optimum therapeutic management. But, it still remains a challenge in the field of pharmaceuticals for delivery of ionic species such as proteins and peptides. Development of iontophoretic system is a breakthrough in this field designed to improve the delivery rate of ionic compounds. This technique generates an electrical potential gradient that facilitates the movement of solute ions across the membrane. Moreover with the advent of more sophisticated techniques available for the production of recombinant proteins and peptides, there is an ever-increasing demand of novel delivery systems that could effectively deliver these ionic species at the specific site. Iontophoresis seems to be an ideal candidate to sort out the limitations associated with the delivery of ionic drugs. This delivery system utilizes electric current as a driving force for permeation of ionic and non-ionic medications. The rationale behind using this technique is to reversibly alter the barrier properties of skin, which could possibly improve the penetration of drugs such as proteins, peptides and other macromolecules to increase the systemic delivery of high molecular weight compounds with controlled input kinetics and minimum inter-subject variability. The controlled or feed back iontophoretic drug delivery may include the use of polymeric system responsive to an oscillation magnetic field, temperature sensitive polymers, polymers responsive to externally applied ultrasound and chemically sensitive polymers. The iontophoretic delivery of macromolecules will open the doors to non-invasive transdermal delivery of peptide-based pharmaceuticals, following the advances in recombinant DNA technology, which are the wonder drugs of tomorrow.
Authors and Affiliations
Sampath Kumar KP, Debjit Bhowmik, Jyoti Jaiswal
Keywords
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