Reduced Sampling Schedules for Calculation of an Insulin Sensitivity Index from the Liquid Meal Tolerance Test
Journal Title: Diabetes Research – Open Journal - Year 2015, Vol 1, Issue 1
Abstract
Background: The objective of this study was to evaluate the performance of the Matsuda index of insulin sensitivity (MISI) calculated using reduced sampling schedules. Methods: Relationships between MISI values from a Liquid Meal Tolerance Test (LMTT) and insulin sensitivity (SI ) derived from an intravenous glucose tolerance test were assessed in 24 overweight/obese subjects (67% women) without diabetes. Results: Significant correlations were found between SI and 1) MISI calculated from 0, 30, 60, 90, and 120 min (r=0.776, p<0.0001); 2) MISI calculated from 0, 60, and 120 min (r=0.815, p<0.0001); and 3) MISI calculated from and 0 and 120 min (r=0.848, p<0.0001). Conclusion: MISI from LMTTs calculated using reduced sampling schedules (0, 60, 120 min or 0, 120 min) may be useful, lower cost options for assessment of insulin sensitivity in population studies and large clinical trials.
Authors and Affiliations
Chad M. Cook
Keywords
Related Articles
- EP ID EP549350
- DOI 10.17140/DROJ-1-104
- Views 158
- Downloads 0
Regulatory T-Cells in Treatment of Type-1 Diabetes: Types and Approaches
Regulatory T-cells (Tregs) play important role in regulation of immune responses to self-antigens. Alterations in frequency and function of Tregs have been reported in Type 1 Diabetes (T1D) subjects. Tregs have the poten...
Population-Based Strategy for Preventing Diabetes and its Complications
A recent report from the American College of Physicians (ACP) should cause a paradigm change for the treatment of diabetic patients.1 The main purpose of diabetes therapy is the prevention of complications.2 The endpoi...
Type 1 Diabetic and Hypertensive Retinopathy: Case Presentation and Review of Literature
Background: Type 1 Diabetes (T1D) Mellitus is a complex, chronic illness that affects half a million children under the age of 15 years. Complications associated with diabetic retinopathy can be prevented with continued...
Combination Treatment with a Novel Polyherbal Formulation and Metformin: A Single Blind Placebo-Controlled Study in Patients with T2DM and Cognitive Impairments
Background: Older people suffering from Type 2 Diabetes Mellitus (T2DM) are at major risk for age related cognitive dysfunction and dementia, mainly due to vascular complications. Studies have shown that T2DM is also ass...
Glycemic Variability: Clinical and Prognostic Significance
Minimizing development or progression of chronic diabetic micro and macro-vascular complications has been always the goal of glycemic control. In recent years, much attention has been focused on the possibility that glyc...