Regulation in Cell Cycle via p53 and PTEN Tumor Suppressors
Journal Title: Cancer Studies & Molecular Medicine – Open Journal - Year 2014, Vol 1, Issue 1
Abstract
One of the target effectors of p53 transcription factor is the Phosphatase and Tensin homologue deleted on chromosome 10 (PTEN) which has protein phosphatase activity and lipid phosphatase activity that antagonizes PI3K activity. Cells that lack PTEN have constitutively higher levels of PIP3 and activated downstream targets. Both p53 and PTEN are tumor suppressors that act by inhibiting cell cycle progression and promoting apoptosis. Germline mutations in p53 and PTEN cause Li-Fraumeni syndrome and Cowden syndrome, respectively. The p53 cooperates with PTEN, which might be an essential blockage in development of cancers. PTEN protects p53 from MDM2-mediated degradation, whereas p53 can enhance the transcription of PTEN. This review summarizes the function of PTEN and p53 in cell cycle regulation. We will also discuss the role of PTEN signaling through its interaction with p53 and MDM2 pathways for the potential implications in the cell cycle regulation.
Authors and Affiliations
Satoru Matsuda
Keywords
Related Articles
- EP ID EP552497
- DOI 10.17140/CSMMOJ-1-101
- Views 122
- Downloads 0
Flavones and Flavonols may have Clinical Potential as CK2 Inhibitors in Cancer Therapy
The serine-threonine kinase CK2, which targets over 300 cellular proteins, is over expressed in all cancers, presumably reflecting its ability to promote proliferation, spread, and survival through a wide range of comple...
Boosting Response: The Impact of Immune Checkpoint Inhibitors on Radiation Treatment Schedules
The recent FDA approvals of immunomodulatory drugs such as Nivoluvamab (Opdivo), Pembrolizumab (Keytruda) and Ipilimumab (Yervoy) for treatment of Non-small cell lung cancer (NSCLC) and melanoma have renewed interest in...
The Emerging Spectrum of Early Life Exposure-Related Inflammation and Epigenetic Therapy
Early life exposure to a variety of insults during sensitive windows of development can reprogram normal physiological responses and alter disease susceptibility later in life. During this process, inflammation triggered...
Long Term, Low Dose Genistein decreases Stem Cell Populations and Sensitizes Inflammatory Breast Cancer Cell Lines to Radiation
Local recurrence in inflammatory breast cancer is common and is associated with poor prognosis. Recurrence is driven by a small population of radioresistant breast cancer cells that have stem-like properties. Previous st...
Rounding Down Chemotherapeutic Agents to the Nearest Vial Size as a Cost Containment Measure
Background: High cancer treatment costs significantly affect health care expenditures. Drug waste reduction of costly drugs can reduce the treatment cost. Methods: A retrospective study conducted at King Abdulaziz Medica...