Relationship between adiponectin levels and metabolic syndrome components in obese children and adolescents

Journal Title: Postępy Nauk Medycznych - Year 2014, Vol 27, Issue 10

Abstract

Introduction. Adiponectin is an adipocyte-derived multiple function protein involved in metabolic syndrome pathogenesis of children.Aim. The aim of the study was to assess the correlation between adiponectin levels and the metabolic syndrome and its components in obese children and adolescents.Material and methods. The study included 122 obese children (52 girls, 70 boys, aged 5.3-17.9 years) and a control group of 58 normal-weight children. Obesity was defined according to IOTF criteria. Anthropometric measurements and blood samples were taken from each participant. Adiponectin levels were assessed using the radioimmunoassay (RIA) method. HOMA was calculated to estimate the degree of insulin resistance. Metabolic syndrome components were applied using the 2007 IDF criteria.Results. The metabolic syndrome (MetS) was diagnosed in 20.2% of the study group. The plasma adiponectin levels were significantly lower in obese children than in the control group. Lower mean adiponectin levels were found in obese children with MetS criteria as compared to those without. In study and control groups of children considered as a whole the adiponectin levels were correlated with BMI, BMI SDS, HDL-C and CRP. The correlation with HDL-C was observed in the obese group only. Logistic regression analysis demonstrated that a 1 unit increase in adiponectin level results in a 0.9 fold reduction of the risk of a low < 40 mg/dl HDL-C level.Conclusions. Adiponectin may be associated with the metabolic syndrome through its impact on HDL-C and inflammation.

Authors and Affiliations

Małgorzata Rumińska, Anna Majcher, Beata Pyrżak, Aneta Czerwonogrodzka-Senczyna, Ewelina Witkowska-Sędek, Danuta Janczarska

Keywords

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  • EP ID EP54826
  • DOI -
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How To Cite

Małgorzata Rumińska, Anna Majcher, Beata Pyrżak, Aneta Czerwonogrodzka-Senczyna, Ewelina Witkowska-Sędek, Danuta Janczarska (2014). Relationship between adiponectin levels and metabolic syndrome components in obese children and adolescents. Postępy Nauk Medycznych, 27(10), -. https://europub.co.uk/articles/-A-54826