Relationship between chronic obstructive pulmonary disease and levels of vitamin D
Journal Title: Dicle Tıp Dergisi - Year 2015, Vol 42, Issue 2
Abstract
Objective: Vitamin D deficiency may be associated with pulmonary function deterioration. The aim of this study is to assess the relationship of serum vitamin D levels with pulmonary functions, disease severity and exacerbation frequency in Chronic Obstructive Pulmonary Disease (COPD) patients. Methods: Seventy consecutive patients with COPD (Global Initiative for Chronic Obstructive Lung Disease (GOLD) stage II-IV) who presented to our outpatient clinic and thirdty controls entered to the study. Diagnosis of COPD was confirmed according to clinical findings and pulmonary function test. Serum 25-hydroxyvitamin D (25(OH)D levels were measured by immunofluorescence method. Levels <20 ng/mL defined deficiency. Associations between Vitamin D levels and sex, age, body mass index (BMI), smoking habit, comorbidities, exacerbation frequency were examined. Results: The mean age of patients was 60.7 years. The proportion of patients in stages 2 of GOLD was 40 %, in stages 3 was 30 % and stages 4was 30 %. There was no significant difference in serum levels of 25(OH)D between COPD patients and controls. Vitamin D level was 9.3 ±6.0 ng/mL in control group and 9.7± 8.5 ng/mL in GOLD stage 2, 9.6 ± 6.2 ng/mL in stage 3 and 5.1 ±2.4 ng/mL in stage 4. In stage 4, vitamin D levels was significantly lower statistically (p=0.03). Among the COPD patients, lower FEV1 was associated with lower levels of 25(OH)D (p= 0.03). The most frequent comorbidities were hypertension (61.4%) and heart failure (27.1%). Among the COPD patients smoking associated with significantly lower levels of serum 25(OH) D (p=0.04). We find an association with exacerbation frequency in the previous 12 months and levels of 25(OH) D (p=0.02). Conclusion: COPD severity according to GOLD stage is also associated with low levels of 25(OH)D. Serum vitamin D levels are lower in COPD patients who are current smokers. Severe vitamin D deficiency is related to more frequent disease exacerbations. These findings indicated a relationship between serum 25(OH)D concentrations and COPD which suggests optimization of serum vitamin D levels in COPD. Key words: Pulmonary functions, Vitamin D, COPD
Authors and Affiliations
Buket Çilingir, Hülya Günbatar
Keywords
Related Articles
- EP ID EP163656
- DOI 10.5798/diclemedj.0921.2015.02.0551
- Views 123
- Downloads 0
Histopathologic investigation of the protective effects of omega-3 fatty acids against boric acid-induced injury in kidney and testis tissue
Objective: In this study, it was aimed to evaluate the effects of boric acid on rat kidney and testis tissues histopathologically. Secondly, the protective effects of omega-3 fatty acid against boric acid-induced renal...
Çocukluk Çağı Nefrotik Sendromunda Ortalama Trombosit Hacminin Önemi
Amaç: Ortalama trombosit hacmi (MPV) ve trombosit sayısı pek çok kronik enflamatuar hastalıkta yüksek saptanmış ve prognoz ile ilişkili bulunmuştur. Bu çalışmada çocukluk çağı nefrotik sendromunda MPV’ nin önemini ve ste...
An important cause of tetraparesis: Cervical spondylotic myelopathy
Cervical spondylotic myelopathy which is a neurologic disorder caused by degenerative changes in the cervical spines related to narrowing in the spinal channel. Spondylosis may cause myelopathy effecting spinal...
The Effect of Overweight Status on Total and Metastatic Number of Harvested Lymph Nodes During Colorectal Surgery
Objective: The aim of this study is to evaluate the relationship between higher body mass index (BMI) and harvested total or metastatic lymph node numbers in patients who underwent surgery for colorectal cancers....
Vernal keratokonjonktivitte gözyaşı interlökin-16 düzeyleri
Amaç: Vernal keratokonjonktivit genellikle atopik öyküye sahip çocuklarda ve genç erişkinlerde gözlenir. Bu çalışmada vernal konjonktivitli hastalarda gözyaşı İnterlö- kin-16 (IL-16) düzeyini incelenmesi amaçlan...