Relationship between Helicobacter pylori infection and spontaneous abortion: A Systematic Review and meta-analysis
Journal Title: INTERNATIONAL JOURNAL OF CURRENT RESEARCH IN MEDICAL SCIENCES - Year 2018, Vol 4, Issue 10
Abstract
Introduction: Abortion is one of the most common complications of pregnancy. Infection is one of the main causes of abortion, a cause which is more important in spontaneous abortion; infections account for only 5% of recurrent abortions. Helicobacter pylori is a gram-negative movable bacterium and urease enzymes. The aim of this study is to determine the Relationship between Helicobacter pylori infection and spontaneous abortion. Method: the methods used for this systematic review were based on the "Cochrane Systematic Study Booklet" and "Appropriate Items for Systematic and Meta-Analysis Study (PRISMA)" tool. To find references, the international Databases (MEDLINE PubMed interface), Google Scholar, and Web of Science) and domestic databases (SIDs and Magiran) and journals were searched; unlimited searching, in terms of both setting and language, was done until June 30, 2018.following keywords were used to provide a comprehensive context: helicobacter pylori; Abortion; spontaneous abortion; H. pylori; relationship; miscariage; Gastritis. Result: Based on the results of random effects model, the Relationship between Helicobacter pylori infection and spontaneous abortion in Pregnant women in 227 patients was 1.41 (95% confidence interval [CI]: 1.04, 1.93, I2 = 83.5%) (p = 0.014 ) . Discussion and conclusion: Based on the results of the present systematic study, there is a significant relationship between Helicobacter pylori infection and abortion. Among the factors associated with HP inflammation during pregnancy, complications such as iron deficiency anemia and nausea in pregnancy are associated with a high prevalence of Helicobacter pylori especially in developing countries. More extensive research is needed in this domain, because this specific type of inflammation is preventable with timely treatment.
Authors and Affiliations
Zahra Shahraki
Keywords
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- EP ID EP549413
- DOI 10.22192/ijcrms.2018.04.10.010
- Views 118
- Downloads 0
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