Relationship between Iron Storage, Anti Oxidant Status and Number of Transfusion In Beta-Thalassemia Patients: A CrossSectional Study
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2018, Vol 17, Issue 5
Abstract
Blood transfusionis the most common therapeutic aspect as well as life-saving measure for βthalassaemic major patients but repeated transfusion is related to iron overload and storage in the body and if untreated it may cause considerable morbidity and enhance early mortality. All serum anti-oxidant including glutathione is also altered due to iron-induced peroxidative injury. However, few studies can be found in India describing the relationship between iron storage, antioxidant status and number of transfusion in β-thalassemia major patients. The present study was carried out to evaluate a relationship between iron storage, anti-oxidant status and number of transfusion in proved cases of β-thalassemia major of Indian origin. Present study confirms thatincreased no of transfusion led to more iron strorage in body and Red blood cells- reduced glutathione (RBC- GSH) is directly correlated with iron storage.
Authors and Affiliations
Tanima Mandal, Anindya Dasgupta, Chandan Sarkar, Keya Basu, Sumanta Banerjee
Keywords
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