Relationship between Iron Storage, Anti Oxidant Status and Number of Transfusion In Beta-Thalassemia Patients: A CrossSectional Study
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2018, Vol 17, Issue 5
Abstract
Blood transfusionis the most common therapeutic aspect as well as life-saving measure for βthalassaemic major patients but repeated transfusion is related to iron overload and storage in the body and if untreated it may cause considerable morbidity and enhance early mortality. All serum anti-oxidant including glutathione is also altered due to iron-induced peroxidative injury. However, few studies can be found in India describing the relationship between iron storage, antioxidant status and number of transfusion in β-thalassemia major patients. The present study was carried out to evaluate a relationship between iron storage, anti-oxidant status and number of transfusion in proved cases of β-thalassemia major of Indian origin. Present study confirms thatincreased no of transfusion led to more iron strorage in body and Red blood cells- reduced glutathione (RBC- GSH) is directly correlated with iron storage.
Authors and Affiliations
Tanima Mandal, Anindya Dasgupta, Chandan Sarkar, Keya Basu, Sumanta Banerjee
Keywords
Related Articles
- EP ID EP374492
- DOI 10.9790/0853-1705052629.
- Views 58
- Downloads 0
Correlation between Pulmonary Tuberculosis, Bronchiectasis and Chronic obstructive pulmonary disease in Burdwan District of West Bengal, India
Introduction: Tuberculosis is very prevalent in India .According to WHO TB statistics about40%popoulatin of India having tuberculosis infection till 2016. Inspite of having complete course of anti-tuberculosis therapy pa...
Caries Research in the Modern Era… Where Are We Now? A Review.
Dental caries is an age old disease that has plagued humans ever since existence. The multifactorial etiology of dental caries and the preventive therapies in modulating cariogenic bacteria have witnessed paradigm shifts...
Comparative Study on Root Canal therapy Preparation with Rotating Tools Protaper Gold And Hyflex cm
Aim: In the case of teeth clinically diagnosed with acute pulp irritation or complicated gangrene with periradicular lesions, endodontic treatment is the choice used by practitioners. The purpose of this in vitro study i...
Management of Complicated Crown-Root Fracture by FragmentReattachment Using Fibre-Post: An Aesthetic Alternative
The advances in adhesive dentistry have allowed dentists to use the patient’s own fragment to restore the fractured tooth. The present case report describes management of a complicated fracture of maxillary right central...
Interrelationship Amongst Selected Metabolic Markers andBody Fat Distribution ofSedentary Mid Age Men
The objective of the present study was to find out the relationship between body fat distribution and selected metabolic variables of Bengalee mid-age males who confine themselves within physical activities required for...