Relationship between Serum Ferritin Levels and Biochemical Markers of Bone Turnover in Postmenopausal Women
Journal Title: Vajira Medical Journal: Journal of Urban Medicine - Year 2020, Vol 64, Issue 4
Abstract
Objective: To study the relationship between serum ferritin levels and biochemical markers of bone turnover in postmenopausal women. Methods: This cross-sectional study was conducted at the Department of Obstetrics and Gynecology, Faculty of Medicine Vajira Hospital, Bangkok, Thailand. One hundred and twenty four postmenopausal Thai women were recruited from menopause clinic between December 2015 and March 2016. The inclusion criteria were age 40 years or more, body mass index (BMI) of 19-30 kg/m2, not use menopausal hormone therapy (MHT) within the last 3 months, adequate cessation period of any bone antiresorptive agent, no underlying disease which possibly associated with chronic anemia, and no history of steroid hormone, anabolic agent, or anticoagulant use. The subjects were excluded if their blood specimens were unsuccessfully collected or incompletely analyzed. Two kinds of biochemical markers of bone turnover were selected to study. The first one was a bone-formation marker, called procollagen type I N- terminal propeptide (P1NP) and the second was a bone-resorption marker, namely C-terminal cross-linked telopeptide of type I collagen (CTx). Each marker was evaluated its relationship to serum ferritin. Results: After recruitment, one subject was excluded because her blood specimen was loss during transfer, therefore 123 cases were left for analysis. Mean (SD) age, BMI, duration of menopause, and number of parity of the overall subjects were 56.8 (4.2) years, 24.3 (3.1) kg/m2, 7.1 (5.3) years, and 1.3 (1.1), respectively. Mean (SD) serum ferritin, P1NP, and CTx levels were 147.75 (95.11), 63.90 (16.70), and 0.463 (0.154) ng/ml, respectively. Serum ferritin levels were negatively correlated with P1NP and with CTx levels (r = -0.149, p = 0.099 and r = -0.038, p = 0.677, respectively). Conclusion: Serum ferritin levels had non-significant inverse relationship with P1NP and CTx levels in postmenopausal women. The long-term effects of low iron storage on biochemical markers of bone turnover are needed to be further evaluated.
Authors and Affiliations
Somnimit Luengratsameerung
Keywords
Related Articles
- EP ID EP723274
- DOI http://dx.doi.org/10.14456/vmj.2020.28
- Views 60
- Downloads 0
Food Consumption Behaviors of Third-Year to Fifth-Year Medical Students at the Faculty of Medicine Vajira Hospital
Objective: To study the food consumption behaviors, attitudes towards food consumption and factors relating to food consumption behaviors of third-year to fifth-year medical students at the Faculty of Medicine Vajira Hos...
Antibody Response after ChAdOx1 nCoV-19 Vaccination in Patients with Type 2 Diabetes at Vajira Hospital
OBJECTIVE: A question exists as to whether people with diabetes can respond effectively to the COVID-19 vaccine. This study aimed to evaluate antibody response after COVID-19 vaccination in patients with type 2 diabetes....
Prosperity of celecoxib for pain relief after elective cesarean delivery, a double-blind randomized controlled trial
Objective: To determine the effectiveness of 400-mg celecoxib after elective cesarean delivery. Methods: In this randomized double blinded controlled trial, 110 full-term pregnant women aged between 20-40 years old who...
Adverse outcomes in advanced maternal age: A case-control study
Objective: To compare pregnancy outcomes between women aged 35 years and older with those under 35 years old. Methods: A retrospective cohort study was conducted at Vajira hospital, Navamindradhiraj University from 1 Oc...
The Effect of Damper on Tennis Racket Handle Impact Force after Ball Impaction
Objective: To compare the peak force and vibration at tennis racket grip between different dampers and different tennis ball impact locations. Methods: The peak force and vibration was measured at tennis rackets grips b...