RELATIONSHIP BETWEEN UNDERCARBOXYLATED OSTEOCALCIN AND OSTEOPROTEGERIN IN KNEE OSTEOARTHRITIS
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2014, Vol 6, Issue 11
Abstract
Objective: The purpose of the present study was to evaluate the possible association between the serum levels of undercarboxylated osteocalcin (ucOC) and osteoprotegerin (OPG) in patients with knee osteoarthritis (OA).Methods: Twenty patients (10 men and 10 women) diagnosed to have knee OA, and twenty healthy subjects of matching age, sex, and BMI as a control group, were enrolled in this study. Serum levels of ucOC and OPG, were assayed using the corresponding human ELISA kits.Results: Patients with knee OA, showed a statistically significant elevation in serum levels of ucOC (P<0.001), and a statistically significant reduction in that of OPG (P<0.0001), as compared to the control group. Also, there is significant negative correlation (r=-0.554, p= 0.0113) between the serum levels of ucOC and OPG in knee OA patients.Conclusion: there is possible association between the serum levels of ucOC and OPG in patients with knee OA.Â
Authors and Affiliations
Shatha H Ali, Ali A. Kassim
Keywords
Related Articles
- EP ID EP579317
- DOI -
- Views 87
- Downloads 0
STABILITY INDICATING CHROMATOGRAPHIC METHODS FOR THE DETERMINATION OF PHARMACEUTICAL DOSAGE FORMS CONTAINING CALCIUM DOBESILATE IN THE PRESENCE OF ITS INTERFERING SUBSTANCES
Objective: Two simple, accurate and precise chromatographic methods were developed for the determination of calcium dobesilate in the presence of its interfering substances as its degradation product and/or impurity hydr...
A GLOBAL COMPARISON AND ANALYSIS OF NEURAMINIDASE H1N1 STRAIN OF INFLUENZA A
Objective: To evaluate the variation of neuraminidase (NA) protein from various H1N1 strain for drug designing.Methods: In this study we have used 12 sequences of NA protein from various countries, retrieved from Uniprot...
POST-MARKETING PASSIVE SURVEILLANCE OFBIVALENT AND QUADRIVALENT HUMAN PAPILLOMAVIRUS RECOMBINANT VACCINES
Objective: Cervical cancer and other Human papillomavirus associated malignancies might be prevented by Human papillomavirus vaccines namely Gardasil® (HPV4) - quadrivalent (Merck) and Cervarix™ (HPV2) - bivalent (Gla...
IN VITRO ANTI-OBESITY EFFECT OF MACROLICHENS HETERODERMIA LEUCOMELOS AND RAMALINA CELASTRI BY PANCREATIC LIPASE INHIBITORY ASSAY
Objective: Obesity is a chronic disorder caused by an imbalance between energy intake and expenditure in which excessive fat will be deposited in adipose tissue and poses a risk to the health and well-being of humans. Ag...
EFFECT OF HEAT AND FILTER STERILIZATION ON THE EFFICIENCY OF COLEUS AROMATICUS AS AN ANTIBACTERIAL AGENT AGAINST DIABETIC WOUND PATHOGENS
Objective: The purpose of the present study is to evaluate the effect of sterilization on the efficiency of Coleus aromaticus on eradicating diabetic wound pathogens. Methods: The investigation was explored by deploying...