Relationships between Weight, Adiposity, Functional Status, and Left Ventricle Characteristics in Overweight and Obese Patients with Heart Failure
Journal Title: Journal of Diabetes and Obesity - Year 2017, Vol 4, Issue 2
Abstract
Aims: This study was conducted to examine the relationship between adiposity and functional status (i.e. peak oxygen consumption [VO2max]), and left ventricular (LV) structural characteristics (i.e., LV ejection fraction [LVEF], LV end diastolic dimension [LVEDD], LV posterior wall thickness [LVPWT]) in heart failure (HF) patients with diabetes mellitus (DM), and/or metabolic syndrome (MS). We hypothesize that excess weight and body fat are significantly related to cardiac functional status. Methods and Results: Ninety four patients’ clinical characteristics were analyzed at baseline to examine the relationships of interest. Results show that weight was correlated with fat and lean mass and LVEF (all p’s < 0.050). Novel findings from our data showed that weight, fat mass, and percent fat were inversely related to VO2 max; weight, fat mass and lean mass were positively related with LVPWT. In a multivariate analysis, body mass index and fat mass accounted for 28.8% of the variance in VO2 max, showing significantly higher predictive value than other covariates (P = 0.002). Conclusions: Our findings show a possible relationship between body fat on functional status in this patient cohort and challenges existing research that supports that higher weight and increased fat are good in the setting of chronic HF (i.e. obesity paradox). Strategies to optimize weight and reduce adiposity warrants further investigation in this subgroup of patients.
Authors and Affiliations
MARJAN Motie
Keywords
Related Articles
- EP ID EP417859
- DOI 10.15436/2376-0494.17.1108
- Views 64
- Downloads 0
Occurrence of Left Ventricular Hypertrophy in Subjects with Metabolic Syndrome: Role of Adiponectin
This study was designed to evaluate the role of total plasma adiponectin ADPN on the occurrence of left ventricular hypertrophy in subjects with metabolic syndrome MetS compared to a control group without MetS The m...
Differential Association of Niemann-Pick C1 Gene Polymorphisms with Maternal Prepregnancy Overweight - Gestational Diabetes
A genome-wide association study GWAS - subsequent replication studies in diverse ethnic groups indicate that common Niemann-Pick C1 gene NPC1 polymorphisms are associated with morbid-adult obesity or diabetes indepen...
Possibility of Diabetes Prevention by High-amylose Rice and Super Hard Rice
Diabetes is one of the most devastating diseases in the world Its prevention is very important in addition to the development of the curing technology We started the cooperative research on low Glycemic Index GI rice...
Clinical Outcomes in Patients with Diabetes Mellitus Using a Medically Supervised Commercial Weight Reduction Program Compared to Standard Care in an Endocrine Specialty Clinic
Aims: To evaluate metabolic and anthropometric changes achieved and maintained by diabetic patients (pts) in a structured weight loss (WL) program vs usual care in an endocrine clinic (UCG). Materials and Methods: This r...
Effect of Three Methods of Approaching Obesity in Long- Term Weight Loss
Objective: To analyze the effect on weight reduction in overweight and obese patients through three intervention methods. Material and methods: Prospective, randomized, multicentric intervention study in overweight and o...