Remission of Glucocorticoid-Resistant Polymyalgia Rheumatica achieved with Tocilizumab: 2 Case Reports
Journal Title: Rheumatica Acta: Open Access - Year 2017, Vol 1, Issue 1
Abstract
Polymyalgia rheumatica (PMR) is an idiopathic inflammatory disease characterized by pain and stiffness around the shoulders, neck and hips. IL-6 is an important cytokine in the pathogenesis of the disease. Although glucocorticoids (GC) are the current basic treatment, approximately 50% of patients may experience relapses during treatment. There have been case reports of resistant patients treated with Tocilizumab (TCZ), but as there has been insufficient evidence, the 2015 EULAR-ACR did not include TCZ treatment in the PMR recommendations. Two cases of GC-resistant PMR cases where remission was obtained with TCZ treatment are presented in this paper.
Authors and Affiliations
Enginar Ayse Unal
Keywords
Related Articles
- EP ID EP543100
- DOI 10.17352/raoa.000007
- Views 66
- Downloads 0
Remission of Glucocorticoid-Resistant Polymyalgia Rheumatica achieved with Tocilizumab: 2 Case Reports
Polymyalgia rheumatica (PMR) is an idiopathic inflammatory disease characterized by pain and stiffness around the shoulders, neck and hips. IL-6 is an important cytokine in the pathogenesis of the disease. Although gluco...
The Complexity of DNA Transcends Epigenetics
Availability of new has afforded rheumatologists the opportunity to investigate molecular pathophysiology of joint disease techniques [1,2]. Attempts to relate DNA polymorphisms to disease activity or addresses one aspec...
Idiopathic Intracranial Hypertension: Neuropsychiatric Systemic Lupus Erythematosus or Gonadotropin- releasing hormone agonist side effect?
A 31-year-old systemic lupus erythematotus (SLE) patient presented with headache and blurring of vision. Prior to this, she received 2 doses of monthly triptorelin for endometriosis. On examination, she had bilateral six...
Laryngeal Primary Amyloidosis: Differential Diagnosis of Localized Granulomatosis with Polyangiitis. Report of Two Cases
Primary laryngeal amyloidosis (PLA) and granulomatosis with polyangiitis (GPA) can present rarely with the isolated symptom of dyspnea and/or dysphonia, affecting exclusively the larynx. Granulomatosis with polyangiitis...
Eosinophilic Fasciitis in a Patient with Hepatitis C Virus Infection: Coincidence or Association?
Eosinophilic fasciitis is a rare connective tissue disease characterized by symmetrical and painful swelling with a progressive induration and thickening of the skin and soft tissues. Its etiology is unknown, but possibl...