Renal Glucosuria-Most Frequent Condition with Positive Urine Glucose in A Screening Program at School
Journal Title: Biomedical Journal of Scientific & Technical Research (BJSTR) - Year 2018, Vol 7, Issue 3
Abstract
Renal glucosuria (RG) is a disorder of proximal tubular glucose transport, characterized by abnormal urinary excretion of glucose in the absence of impaired glucose metabolism. In some affected families, RG is caused by homozygosity or compound heterozygosity of mutations in the SCL5A2 gene, encoding the renal-specific sodium/glucose cotransporter 2. Some children are detected as urine glucose positive with no evidence of hyperglycemia in a screening program at school, and are diagnosed as having RG. We found about 30% of Japanese school students with a positive result at a urine glucose screening program at school was diagnosed with diabetes. On the other hand, the others, almost 70% of cases, with positive urine glucose was finally identified as having RG with no evidence of glucose intolerance in the detailed examination. They had a strong family history of RG. We conclude that RG may be not rare, but a frequent condition with glucosuria among Japanese school children. Marble [1] defined clinical diagnostic criteria in RG, and the condition was revealed to be autosomal recessive and uncommon. These criteria included normal plasma glucose (PG) level on oral glucose tolerance test (OGTT), normal plasma levels of insulin and glycosylated hemoglobin (HbA1c), and relative stable urinary excretion of glucose (10-100 g/day) in all urine specimen Lawrence [2] later proposed another criterion as normal glucose tolerance on OGTT, regardless of the presence of glucosuria in the fasting state. Cases fulfilling Marble’s criteria appear to be few, whereas, Desjeux [3] reported that about 60% of subjects with positive urine glucose were diagnosed as having RG based on the criteria proposed by Lawrence. In some affected families, RG is caused by homozygosity or compound heterozygosity of mutations in the SCL5A2 gene, encoding the renal-specific sodium/glucose cotransporter (SGLT) 2 [4-6]. SGLT2 is known to be the principal transporter that mediates glucose resorption [7]. Two major forms of SGLT, SGLT1 and SGLT2, are independently expressed in the renal proximal tubular cells and they are shown to be responsible for glucose reabsorption from glomerular filtrate. SGLT1 is predominantly expressed in enterocytes, with the major function of active glucose and galactose transport. Although not involved in resorption of the bulk of glucose in the kidney, the characteristics of SGLT1 are favorable for glucose transport when present at low concentrations. On the other hand, SGLT2 is predominantly expressed in the luminal brush border of the proximal tubule and is responsible for the vast majority of glucose reabsorption from glomerular filtrate [8]. Familial RG is known to be caused by mutations in the SCL5A2 gene, encoding SGLT2, and is classified into 3 types according to urinary excretion of glucose levels. Subjects with type A RG are characterized by a low renal threshold for glucose and a low maximum tubular glucose reabsorption. Those with type B show a low threshold but exhibit normal maximum tubular glucose reabsorption. On the other hand, subjects with type O show complete absence of renal glucose transport [8]. Individuals with homozygous mutations in the SCL5A2 gene exhibit persistent heavy glucosuria and are designated as type O, whereas those with heterozygous mutations show mild or trait glucosuria [9].
Authors and Affiliations
Junichi Suzuki, Tatsuhiko Urakami
Keywords
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- EP ID EP592886
- DOI 10.26717/BJSTR.2018.07.001506
- Views 170
- Downloads 0
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