Renoprotective Effect of Sitagliptin ( Dipeptidyl Peptidase- 4 Inhibitor) aganist Cisplatin Induced Nephrotoxicity in Mice
Journal Title: Journal of Pharmaceutical Research International - Year 2014, Vol 4, Issue 9
Abstract
Back Ground and Objectives: Despite the therapeutic benefits of cisplatin(CDDP) , its use clinically is often limited due to dose-related nephrotoxicity. Meanwhile, DPP 4 inhibitors could attenuate kidney injury, so the present work aimed to investigate the effect of one of DPP 4 inhibitors (sitagliptin) on cisplatin induced nephrotoxicity in mice . Materials and Methods: 48 male balb-c mice were equally divided into 4 groups, control, sitagliptin group, cisplatin group and cisplatin plus sitagliptin group. The mice were sacrificed at 72 h after cisplatin injection. Blood urea nitrogen (BUN) & serum creatinine, renal tissue of antioxidant enzymes, lipid peroxidation, TNF-alpha (TNF-α) were measured as well as histopathological scoring of renal injury. Results: The results demonstrated that sitagliptin significantly ameliorated the nephrotoxic effect of cisplatin with increased activity of antioxidant enzymes, improved kidney function, renal histopathological scoring and decreased tissue level of TNF-α. Conclusions: It can be concluded that sitagliptin may play a protective effect against cisplatin induced acute nephrotoxicity via antioxidant and anti-inflammatory pathway.
Authors and Affiliations
Amany Shalaby, Hala Abdel Malek
Keywords
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- EP ID EP344917
- DOI 10.9734/BJPR/2014/9297
- Views 108
- Downloads 0
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