Study on Effectiveness of Adding Phenobarbitone to Conventional Therapy in Preterm Neonates with Unconjugated Hyperbiliurubinemia in Comparison with Conventional Therapy
Journal Title: Journal of Pharmaceutical Research International - Year 2016, Vol 9, Issue 5
Abstract
Aim: To assess the effectiveness of adding prophylactic phenobarbitone to conventional therapy in preterm neonatal jaundice in reducing the incidence, peak serum bilirubin levels, duration and need of Phototherapy in the treatment and time taken for complete clearance of jaundice. Background: Neonatal unconjugated hyperbilirubinemia is a life threatening. The conventional therapy is a long time process & some of neonate cannot tolerate for long-term phototherapy. Adding of phenobarbitone to the conventional therapy gives better results. Study Design: A prospective observational study in comparison with retrospective data & it was conducted in the 6 months period i.e., from February 2015 to July 2015 at GGH guntur. Methodology: In our study a 50 patients of both sex under prospective group to whom oral phenobarbitone was given 3 mg/kg/day and 50 patient case sheets data was analyzed under retrospective group. Preterm neonates admitted in neonatal intensive care unit with body weight >1 kg were included in the study and neonates who are on ventilator and birth weight <1kg were excluded from the study. Effectiveness of phenobarbitone was assessed by comparing prospective group with retrospective group using paired t-test in SPSS software. Results and Discussion: Peak total serum bilirubine values, Duration of phototherapy, Duration of hospital stay were less in prospective group as compare with retrospective group were statistically significant. Peak TSB value was observed earlier in prospective group than in retrospective group and there was no requirement of exchange transfusion in prospective group. There was no requirement of phototherapy in 18 out of 50 neonates in prospective group. Conclusion: We conclude that prophylactic oral phenobarbitone dose of 3 mg/kg/day ± phototherapy is effective in healthy preterm neonates in the treatment of unconjugated hyperbilirubinemia and the beneficial affect was more in Low birth weight neonates than in very low birth weight neonates as compare with phototherapy alone.
Authors and Affiliations
M. Saipriya, D. Vidhyadhari, G. Gowtham, Ranakishore Pelluri, P. Yashodhara, Nadendla Ramarao
Keywords
Related Articles
- EP ID EP342288
- DOI 10.9734/BJPR/2016/22174
- Views 115
- Downloads 0
Studies on a Hydrophilic Cellulose Matrix Derived from Ipomoea batatas Tubers II: Application as a Filler-disintegrant in Piroxicam Orally Dispersible Tablets
Aim: In this work, piroxicam orally dispersible tablets (ODTs) was formulated using a hydrophilic cellulose matrix, I-hydrocel derived from the tubers of Ipomoea batatas as a filler-disintegrant in comparison with avicel...
Comparative Fatty Acids Profiling and Antioxidant Potential of Pawpaw and Watermelon Seed Oils
Seed oils of watermelon, unripe and ripe pawpaw were extracted and analyzed for their fatty acid composition using GC/EIMS, phenolic content and antioxidant potential using free radical scavenging effect on 2, 2-diphenyl...
Pharmacokinetics and Bioequivalence Study of Two Proton Pump Inhibitor Products
Omeprazole (OPZ) efficiently suppresses acid secretion in the parietal cells of the stomach. It is widely recommended as proton pump inhibitor (PPI) in Egypt. Presence of many products containing omeprazole available in...
Effect of Aqueous Extract of Guava (Psidium guajava) Leaf on Blood Glucose and Liver Enzymes in Alloxan Induced Diabetic Rats
Aim: The aim of this study is to determine the effect of aqueous extract of Psidium guajava leaf on blood glucose level and liver enzymes of alloxan –induced diabetic rat. Study Design: The animals were grouped into six...
Anti-Cancerous Efficacy of Alcoholic and Aqueous Extracts from an Endemic Plant Thermopsis turcica on Liver Carcinoma
Aims: Thermopsis turcica (T. turcica) is endemic to Turkey. Its general medicinal properties are obvious, but no investigations have been made in term of its anticancerous efficacy against liver carcinoma. So, the presen...