RENOPROTECTIVE PROPERTY OF Chrysophyllum albidum EXTRACT AGAINST Pb2+-INDUCED NEPHROTOXICITY AND OXIDATIVE STRESS IN WISTAR RATS
Journal Title: INNOVATIVE JOURNAL OF MEDICAL AND HEALTH SCIENCE - Year 2019, Vol 9, Issue 2
Abstract
Nephrotoxicity and myriads of renal disorders are currently on the increase worldwide.This poses a great threat to the medical sector globally thereby necessitating the continuedsearch for bioactive agents with reliable renoprotective property. In this studya flavonoid-rich-extract (FRE) of Chrysophyllum albidum pulp was assessed for protectiveproperty against lead-induced nephrotoxicity in wistar rats. The animals weregrouped into four A, B, C and D and were kept under normal condition for 2-weeks.The positive control group B was administered 2.5mg/kg lead acetate while negativecontrol group A received distilled water only. Animals in group C and D simultaneously(1:1) received 2.5mg/kg lead acetate with 150mg/kg FRE and 2.5mg/kg leadacetate with 250mg/kg FRE respectively. Results revealed that lead caused a significant(P<0.05) increase in level of thiobarbituric acid reactive substances in the kidneywhich was restored in group treated with FRE. Lead also caused significant increasein serum levels of other evaluated kidney indices compared with the control. However,a dose of 250mg/kg FRE brought about a significant (P<0.05) reduction in the levelsof these indices while at 150mg/kg there was no significant effect on the parametersassessed compared with the lead acetate intoxicated group. The results obtainedfrom the in vitro and in vivo studies demonstrated the renoprotective potential ofChrysophyllum albidum pulp flavonoid rich extract.
Authors and Affiliations
Tugbobo, O. S. *,Babatola L. J. , Ajiboye, B. O. , Oyinloye, B. E.
Keywords
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- EP ID EP558920
- DOI 10.15520/ijmhs.v9i2.2462
- Views 42
- Downloads 0
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