REPROGRAMMING OF SOMATIC CELLS TO NEURONS WITH SMALL MOLECULES
Journal Title: Международный научный журнал "Интернаука" - Year 2016, Vol 1, Issue 10
Abstract
Regenerative medicine faced scientific, methodological and ethical barriers in therapeutic treatment of human CNS diseases for decades. First of all the barriers limited the development of stem cell based transplantation therapeutic approaches. In 2006 the breakthrough study of Yamanaka and colleagues encouraged search for effective means to convert differentiated somatic cells of mammals into targeted cell types, including neurons. Small molecules cocktails were found to enable reprogramming of somatic cells with and without ectopic expression of transcriptional factors and enhance reprogramming efficiency. Here we offer a review of the latest studies reporting induction of neurons with small molecules.
Authors and Affiliations
Tatyana Deputatova
Keywords
Related Articles
- EP ID EP236543
- DOI -
- Views 98
- Downloads 0
ТИПЫ ОЛИГОПОЛИСТИЧЕСКИХ РЫНКОВ И ПУТИ ИХ ИССЛЕДОВАНИЯ: РЫНОК ПРИРОДНОГО ГАЗА
В статье обосновано, что европейский рынок природного газа является олигополистическим. Приведен обзор наиболее популярных олигополистических моделей. Обосновано применение модели Штакельберга для исследования рынка прир...
MODERN BANKING IN UKRAINE: CONDITION, PROBLEMS AND WAYS OF IMPROVEMENT IN CONDITIONS OF COMPETITION
In the article reviewed the modern condition and ways to optimize the process of improving banking activities in view of European integration processes which are taking place in the country. The authors determined that t...
DEVELOPMENT OF A MODEL OF FORMATION OF TOLERANCE OF JUNIOR SCHOOLCHILDREN IN THE EDUCATIONAL PROCESS
The article defines and justifies the principles of building a model for the formation of tolerance of junior schoolchildren in the teaching and educational process. It is shown that the development of tolerant culture o...
ROBOT LOCALIZATION AND MAP CONSTRUCTION USING SENSOR DATA
This work describes the problem of map contraction and a robot localization using sensor data and data from a group of other robots. This methodology is called SLAM or CML, Simultaneous Localization and Mapping or Concur...
CONSTRUCTING OF MATHEMATICAL MODEL OF GLOBAL WORLD CONFLICTS
Discrete and continuous mathematical models of global world conflicts were constructed and exact solution of the last one was found.