REPROGRAMMING OF SOMATIC CELLS TO NEURONS WITH SMALL MOLECULES

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REPROGRAMMING OF SOMATIC CELLS TO NEURONS WITH SMALL MOLECULES

Journal Title: Международный научный журнал "Интернаука" - Year 2016, Vol 1, Issue 10

Abstract

Regenerative medicine faced scientific, methodological and ethical barriers in therapeutic treatment of human CNS diseases for decades. First of all the barriers limited the development of stem cell based transplantation therapeutic approaches. In 2006 the breakthrough study of Yamanaka and colleagues encouraged search for effective means to convert differentiated somatic cells of mammals into targeted cell types, including neurons. Small molecules cocktails were found to enable reprogramming of somatic cells with and without ectopic expression of transcriptional factors and enhance reprogramming efficiency. Here we offer a review of the latest studies reporting induction of neurons with small molecules.

Authors and Affiliations

Tatyana Deputatova

Keywords

THE EFFECT OF GULLY EROSION ON THE FORMATION OF SCREES AND ROCK FALLS IN THE SECTOR OF ZABALA, PICHINCHA PROVINCE, ECUADOR

A study was conducted on the effect of the number and length of gullies on the development of rock falls and screes on the eastern slope near the city of Quito in the Equatorial Andes. It has been established that gullie...

EP ID EP236543
DOI -
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