Research advances of endoplasmic reticulum stress in high glucose environment and its related ophthalmic diseases
Journal Title: Guoji Yanke Zazhi - Year 2018, Vol 11, Issue 6
Abstract
Endoplasmic reticulum(ER)is a place where it folds and synthesizes the proteins. ER stress was induced when a variety of physiological and pathological factors happened, under which the protein misfolding occurred, the unfolded protein accumulated and the calcium ion imbalanced in the ER. The ER of high-glucose environment can change the protein redox state and produce reactive oxygen species, which affects the ER channel function and chaperone protein buffer; meanwhile changes the balance of calcium ions; finally induces the formation of ER stress. More and more studies have confirmed that ER stress in high glucose environment can cause a variety of ophthalmic diseases. So we review the recent articles about ER stress of high glucose environment and its related ophthalmic diseases.
Authors and Affiliations
Bing Li
Keywords
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- EP ID EP558509
- DOI 10.3980/j.issn.1672-5123.2018.6.13
- Views 124
- Downloads 0
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