Research progress in per- and polyfluoroalkylsubstances ï¼PFASsï¼ exposure and bone health
Journal Title: Shanghai Journal of Preventive Medicine - Year 2023, Vol 35, Issue 4
Abstract
Per- and polyfluoroalkyl substances ï¼PFASsï¼ are a new type of persistent organic pollutants with global attention. They have shown multiple toxic effects due to their persistent accumulation in human body through exposure to environmental media such as drinking waterï¼ foodï¼ atmosphereï¼ and soil. Howeverï¼ the bone toxicity of PFASs has not attracted enough attention. It is believed that the exposure and accumulation of PFASs in human have a significant impact on the bone healthï¼ especially hindering the healthy bone development in infants and adolescentsï¼ and aggravating the occurrence of bone loss and fracture in the elder populations. This paper will review the research progress of the effects of PFASs exposure on bone health indicators such as bone mineral densityï¼ and discuss the mechanisms of PFAS in bone toxicity. This review will provide references for revealing the effects of PFASs exposure on bone health and their toxic mechanisms.
Authors and Affiliations
XUE Liming,LU Wenyuan,XU Jiale,JIN Yuâe,LU Dasheng,WANG Guoquan,
Keywords
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