Research progress of IgM-enriched human intravenous immunoglobulin products
Journal Title: Chinese Journal of Blood Transfusion - Year 2023, Vol 36, Issue 4
Abstract
Comparing with conventional human intravenous immunoglobulin products (hIVIG), IgM-enriched hIVIG have more advantages in the neutralization of pathogens and related toxins, the regulation of complement activity, secretion of cytokines and immune cell activity, but attention should be paid on its potential adverse reactions. Establishing a more simple and efficient technology for IgM concentration and purification and exploring a superior and safer virus inactivation technique were two prominent concerns in the process of production. At present, only one type of IgM-enriched hIVIG is on sale in global market (Pentaglobin®), but relative experimental research and clinical application is lacking in China. This article aims to provide references for the research and development of production and clinical application of these products in China by reviewing the research progress of IgM-enriched hIVIG at home and abroad in recent years.
Authors and Affiliations
Qing LIU, Shengliang YE, Liyuan ZHU, Xi DU, Li MA, Changqing LI
Keywords
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- EP ID EP738535
- DOI 10.13303/j.cjbt.issn.1004-549x.2023.04.016
- Views 47
- Downloads 0
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