Research progress of IgM-enriched human intravenous immunoglobulin products
Journal Title: Chinese Journal of Blood Transfusion - Year 2023, Vol 36, Issue 4
Abstract
Comparing with conventional human intravenous immunoglobulin products (hIVIG), IgM-enriched hIVIG have more advantages in the neutralization of pathogens and related toxins, the regulation of complement activity, secretion of cytokines and immune cell activity, but attention should be paid on its potential adverse reactions. Establishing a more simple and efficient technology for IgM concentration and purification and exploring a superior and safer virus inactivation technique were two prominent concerns in the process of production. At present, only one type of IgM-enriched hIVIG is on sale in global market (Pentaglobin®), but relative experimental research and clinical application is lacking in China. This article aims to provide references for the research and development of production and clinical application of these products in China by reviewing the research progress of IgM-enriched hIVIG at home and abroad in recent years.
Authors and Affiliations
Qing LIU, Shengliang YE, Liyuan ZHU, Xi DU, Li MA, Changqing LI
Keywords
Related Articles
- EP ID EP738535
- DOI 10.13303/j.cjbt.issn.1004-549x.2023.04.016
- Views 42
- Downloads 0
Quality comparability analysis on production site change of human coagulation factor Ⅷ
Objective To study the quality comparability of human coagulation factor Ⅷ (FⅧ) produced before and after the change of factory site. Methods A comparative study was carried out on quality quantitative indexes, related i...
Screening of hepatitis D virus in blood donors in Dalian
Objective To investigate the prevalence of hepatitis D virus in Dalian blood donors. Methods The samples reactive to HBV in blood screening were selected with the following confirmed results: 1)HBsAg+ &HBV DNA+ ; 2)HBsAg...
Prevalence of blood donation related vasovagal reactions in China: a systematic review and Meta-analysis
Objective To systematically evaluate the incidence of donation related vasovagal reactions (DRVR) in China by Meta-analysis method and discuss the risk factors of DRVR, so as to provide scientific basis for the preventio...
The establishment of a high-resolution melting curve genotyping method for ABCG2*376T allele of Jr(a-) and its distribution frequency study
Objective To establish a high-throughput detection method for ABCG2*376T allele of Jr(a-), and apply it to the study of the frequency of this allele in the Chinese population. Methods The specific primers were designed a...
Prediction of B cell epitopes of CD36 and preparation of MAP
Objective To analyze the structure of CD36, search the possible B cell epitopes and prepare multi-antigen peptides(MAP) with B cell epitopes, so as to provide a preliminary experimental basis for the preparation of CD36...