Research progress on anti-tumor properties of Marsdenia tenacissima
Journal Title: Traditional Medicine Research - Year 2018, Vol 3, Issue 4
Abstract
Tongguanteng (Marsdenia tenacissima), which is mainly distributed in the Yunnan and Guizhou provinces of China, was first recorded in Diannanbencao by Lan Mao of the Ming dynasty of China. According to recent pharmacological studies, the chemical composition of Tongguanteng (Marsdenia tenacissima) is complex and contains C21 steroidal saponins, polysaccharides, alkaloids, and other molecules, which show anti-cancer effects on various tumor cell lines. It inhibits tumor cell proliferation and growth mainly by increasing the expression of apoptosis- and cell cycle-related proteins to promote apoptosis and arrest tumor cells in the G2/M or S phase. Downregulation of the expression of vascular endothelial growth factor-2/A and matrix metalloprotease-2/9 suppresses the formation of the tumor microvasculature, leading to tumor malnutrition, increased expression of interleukin-2, glutathione peroxidase, catalase, and superoxide dismutase, and decreased interleukin-10 and malondialdehyde expression, thereby enhancing immunity and antioxidation in the body. Additionally, inhibition of epidermal growth factor receptor, hepatocyte growth factor receptor, and tyrosine-protein kinase receptor activation enhances the anti-tumor efficacy of epidermal growth factor receptor-tyrosine kinase inhibitors as well as inhibits P-glycoprotein and cytochrome P450 to increase the concentration of anti-tumor drugs in tumor cells.
Authors and Affiliations
Yan-Lan Hu, Shao-Hui Wang, Cui-Wei He, Tong-Xiang Liu
Keywords
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- EP ID EP45228
- DOI 10.12032/TMR201812079
- Views 244
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