Research progress on iron nutritional status of plateletpheresis donors
Journal Title: Chinese Journal of Blood Transfusion - Year 2023, Vol 36, Issue 11
Abstract
Apheresis platelets are extensively utilized in clinical practice due to high purity and minimal side effects. These platelets are primarily obtained from regular blood donors. However, there is no consensus on whether plateletpheresis leads to iron deficiency among blood donors. In recent years, increasing attention has been given to the impact of plateletpheresis on the iron nutritional status of these donors. Numerous studies have indicated a prevalence of iron deficiency among plateletpheresis donors. The process of plateletpheresis involves the loss of red blood cells, which can accumulate over time and disrupt iron metabolism, ultimately resulting in iron deficiency anemia. This condition not only affects the physical well-being of the donors but also leads to a decline in their willingness to donate blood. Blood collection and supply institutions should enhance their focus on the iron nutritional status of plateletpheresis donors and implement various measures, such as intensifying health education regarding the significance of iron supplementation, implementing programs for testing iron deficiency, considering the provision of iron supplements and extending blood donation intervals. It is crucial to prevent iron deficiency in plateletpheresis donors. These institutions should explore calculation models that can predict personalized blood donation intervals and iron supplementation strategies, and seek a balanced approach that is optimal for maintaining adequate collections while safeguarding donor health. The article comprehensively reviews literature at home and abroad on the etiology and hazards of iron deficiency in plateletpheresis donors, as well as detection methods and response measures. It serves as a foundation for developing scientific and reasonable care measures for blood donation, while also achieving personalized and scientific management and recruitment strategies for blood donors.
Authors and Affiliations
Ping XIANG, Ran ZHANG, Jianjing LIU, Li LI, Jun LIU
Keywords
Related Articles
- EP ID EP738705
- DOI 10.13303/j.cjbt.issn.1004-549x.2023.11.025
- Views 45
- Downloads 0
Development of the method for determinating ADCC biological activity of IVIG
Objective To establish a method for determinating the antigen-dependent cell-mediated cytotoxicity (ADCC) of human immunoglobulin (pH4)for intravenous injection (IVIG) on luciferase reporter gene-modified cell assay. Met...
Identification and test methods of rare unexpected antibodies in grassroots medical institutions
Objective To explore how to identify rare unexpected antibodies using routine serology methods in blood transfusion department of grassroots hospitals. Methods A patient with gastrointestinal bleeding with inconsistent f...
Application of anti-idiotypic antibodies in antibody screening and crossmatch tests of patients treated with CD47 monoclonal antibody
Objective To perform pre-transfusion examination and major crossmatch test using CD47 anti-idiotypic antibody (CD47 AID) (method 1) and reagent lack of anti-IgG4 anti-human globulin(method 2) in patients treated with CD4...
Extracellular vesicles in the blood components and their roles in transfusion-related immunomodulation
Extracellular vesicles (EVs) with a variety of bioactive molecules can be continuously secreted during the storage of blood components, which can promote cell-cell interaction and mediate cell-to-cell signal transmission...
Detection and analysis of two drug-induced antibodies in suspicious blood samples from pre-transfusion compatibility tests
Objective To detect the piperacillin and amoxicillin antibodies in suspicious blood samples from pre-transfusion compatibility tests in Wuxi and analyze the general characteristics of them, so as to eliminate the interfe...