Research progress on the interaction between ferroptosis and inflammatory signaling pathway
Journal Title: Chinese Journal of Clinical Research - Year 2024, Vol 37, Issue 12
Abstract
Ferroptosis is a form of cell death characterized by iron-dependent lipid peroxidation and the accumulation of reactive oxygen species, distinct from apoptosis and other forms of cell death. Inflammation is the body’s defense response to stimuli, manifested as redness, swelling, heat, pain, and dysfunction, and an imbalance in the inflammatory response can lead to immune system dysregulation, cellular dysfunction, and death. Increasing researches suggest that the activation of inflammation, including the activation of various inflammation-related signaling pathways, can lead to ferroptosis. This review will focus on the classical inflammatory pathways, including the mitogen-activated protein kinase (MAPK), nuclear factor-κB (NF-κB), Janus kinase/signal transducer and activator of transcription (JAK/STAT), and cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) pathways, and elucidate their roles in ferroptosis, discussing their potential mechanisms in the occurrence of diseases associated with ferroptosis, which contributes to a better understanding of the pathophysiological processes of ferroptosis.
Authors and Affiliations
LI Yaling, BAI Yihua, FAN Yang, HUANG Lilan
Keywords
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- EP ID EP753818
- DOI 10.13429/j.cnki.cjcr.2024.12.022
- Views 8
- Downloads 0
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