Resistance Phenotypes of Bacterial Strains Responsible for Urinary Infections and Bacteraemia among Febrile Children with Sickle Cell Anaemia in Mali
Journal Title: JBR Journal of Clinical Diagnosis and Research - Year 2017, Vol 5, Issue 1
Abstract
The broad-spectrum empiric antibiotic therapy recommended for sickle-cell fever can help to develop bacterial resistance. The purpose of this study is to explore and describe resistance phenotypes of isolated bacterial strains of urinary infections and bacteraemia among febrile children with sickle-cell anaemia. From April 2014 to March 2016, we collected 25 bacterial strains from febrile sickle-cell patients aged 6 months to 15 years. The strain was identified by a conventional standard procedure which includes morphological study, culture and biochemical characteristics of the strain followed by an automated method. Twenty-five (25) bacterial strains were isolated in 25 sickle cell children, comprising 17 SS, 3 SC and 5 S-thalassemia strains. These bacterial strains were isolated in urine (23/25 or 92%) and blood cultures. E. coli, Klebsiella pneumoniae, Enterobacter spp., Serratia ficaria, Raoultella ornithinolytica, Pantoea spp. and Salmonella spp were isolated from urine and blood cultures respectively. All these isolated strains were Enterobacteria, with 56% (14/25) E. coli, 16% (4/25) Klebsiella pneumoniae, 8% (2/25) Salmonella group, 8% (2/25) Enterobacter spp, 4% (1/25) Serratia ficaria, 4% (1/25) Raoultella ornithinolytica, and 4% (1/25) Pantoea spp. More than half of the strains were isolated in female patients (19/25). The antibiogram revealed ESBL-producing strains (28% of 7/25) and Cephalosporinasis (8% or 2/25). The isolated strains showed 4% (1/25) resistance to all the aminoglycosides tested, whereas all the strains isolated from the blood cultures showed a wild phenotype. Resistance to quinolones associated with alteration of gyrA and parC genes was 4% (1/25) for all strains isolated from the blood and urine cultures. The resistance phenotypes of bacterial strains found in our study are variable. This study suggests that we should give more priority to other empirical antibiotherapies that use the molecules of the aminoglycosides and quinolones family for sickle cell children in our context than to those recommended elsewhere.
Authors and Affiliations
Baraika MAG, Guindo A, Sadio Sarro YD, Karim Dembele A, Ali Toure B, Traoré I, Kene S, Traore Y, Kanta M, Tessougue O, Diallo DA, Lekana-Douki JB
Keywords
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- EP ID EP381222
- DOI 10.4172/2376-0311.1000132
- Views 53
- Downloads 0
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