Results of subconjunctival 5-fluorouracil in the management of bleb failure: A case series
Journal Title: Ege Tıp Dergisi - Year 2015, Vol 54, Issue 3
Abstract
Aim: To evaluate the efficacy of 5-Fluorouracil (5-FU) injections in eyes with bleb failure and uncontrolled intraocular pressure (IOP) after trabeculectomy. Materials and Methods: Fifteen eyes of 15 patients (6 female, 9 male) were included in this retrospective study. All patients had trabeculectomy surgery for the treatment of primary open angle glaucoma. During the first year followups, cases with IOP higher than 21 mmHg and ineffective blebs were considered as bleb failure. We used 5-FU subconjunctival injections, in the same concentration (5 mg) but in different numbers, to treat the bleb failure and lower the IOP. The efficacy of the treatment was evaluated. Results: The mean age was 59.3±12.4 years (range 43-74 years). The mean 5-FU injection count was 5.27±1.58 injections (range 2-7). The mean IOP was reduced to 17.07±7.10 mmHg after treatment. There was a statistically significant difference in IOP levels before and after the injections (p<0.05). Conclusion: 5-FU injection treatment is safe and effective for the treatment of bleb failure after trabeculectomy.
Authors and Affiliations
İhsan YILMAZ, Ebru Demet AYGIT, Sevil KARAMAN ERDUR, Ahmet DEMİROK
Keywords
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- EP ID EP342708
- DOI 10.19161/etd.344128
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