Resurgence of pertussis at the age of vaccination: clinical, epidemiological, and molecular aspects
Journal Title: Jornal de Pediatria - Year 2015, Vol 91, Issue 4
Abstract
Objective Report the incidence, epidemiology, clinical features, death, and vaccination status of patients with whooping cough and perform genotypic characterization of isolates of B. pertussis identified in the state of Paraná, during January 2007 to December 2013. Methods Cross-sectional study including 1,209 patients with pertussis. Data were obtained through the Notifiable Diseases Information System (Sistema de Informação de Agravos de Notificação – SINAN) and molecular epidemiology was performed by repetitive sequence-based polymerase chain reaction (rep-PCR; DiversiLab®, bioMerieux, France). Results The incidence of pertussis in the state of Paraná increased sharply from 0.15-0.76 per 100,000 habitants between 2007-2010 to 1.7-4.28 per 100,000 between 2011-2013. Patients with less than 1 year of age were more stricken (67.5%). Fifty-nine children (5%) developed pertussis even after receiving three doses and two diphtheria-tetanus-pertussis (DTP) boosters vaccine. The most common complications were pneumonia (14.5%), otitis (0.9%), and encephalopathy (0.7%). Isolates of B. pertussis were grouped into two groups (G1 and G2) and eight distinct patterns (G1: P1-P5 and G2: P6-P8). Conclusion The resurgence of pertussis should stimulate new research to develop vaccines with greater capacity of protection against current clones and also encourage implementation of new strategies for vaccination in order to reduce the risk of disease in infants.
Authors and Affiliations
Rosângela Torres
Keywords
Related Articles
- EP ID EP557039
- DOI 10.1016/j.jped.2014.09.004
- Views 61
- Downloads 0
Newborn screening for sickle cell disease: necessary but not sufficient
Sickle cell disease is a global health problem that affects>300,000 newborns per year, predominantly in Sub-Saharan Africa,1 where mortality is estimated to be>50% by age 5 years for those with homozygous hemoglobin S (H...
Preventing childhood overweight and obesity
Childhood obesity is widely recognized as a major public health problem of global significance.1 In Latin America, the ever-rising rates of overweight and obesity observed over the past three decades have not spared chil...
Metabolic syndrome in children and adolescents with phenylketonuria
Objective This study aimed to identify markers of metabolic syndrome (MS) in patients with phenylketonuria (PKU). Methods This was a cross-sectional study consisting of 58 PKU patients (ages of 4-15 years): 29 patients...
Clinical course of a cohort of children with non-neurogenic daytime urinary incontinence symptoms followed at a tertiary center
Objective To characterize a cohort of children with non-neurogenic daytime urinary incontinence followed-up in a tertiary center. Methods Retrospective analysis of 50 medical records of children who had attained bladder...
Evaluation of carotid intima-media thickness and factors associated with cardiovascular disease in children and adolescents with chronic kidney disease
Objective To assess the carotid intima-media thickness and factors associated with cardiovascular disease in children and adolescents with chronic kidney disease. Material and methods Observational, cross-sectional study...