“Reticulocyte count production index is most common clinical and hematological laboratory spectrum indicator of Pancytopenic –Hematological disorder”.
Journal Title: International Journal of Medical Science and Diagnosis Research (IJMSDR) - Year 2017, Vol 1, Issue 5
Abstract
OBJECTIVES & AIMS-.1. Investigation of anemia2.Monitoring the effect of hematinic or recombinant erythropoietin therapy 3.Monitoring bone marrow regenerative capacity after chemotherapy or bone marrow transplantation 4.To determine the spectrum of pancytopenia with its frequency and common clinical presentation.5.To observe the utility of the ancillary test in evaluating the bone marrow reactivity. MATERIAL & METHODS The reticulocyte count by conventional microscopy was performed according to a standard protocol routinely used at the hematology laboratory .To 12 × 75 mm polystyrene tubes, aliquots of 50 μl of total blood collected in EDTA and 50 μl of supra vital methylin blue stain o were added to each sample. The mixture was homogenized and incubated during 15 minutes in a water bath, at 37°C, shielded from light. Next, blood films were prepared in glass slides for microscopy. The counting was done using a microscope with 100× immersion objective lenses, and the number of reticulocytes was calculated considering the number of these cells in 1,000 assessed erythrocytes. The results were expressed as reticulocyte percentage values. Result- Reticuolcyte count is good clinical and hematological laboratory spectrum indicator of Pancytopenic –bone marrow disorder. Bone marrow disorder 100 cases study shows megaloblastic anaemia was commonest cause constituting 75.7% followed by aplastic anaemia (15.5%), subleukemic leukemia (3.85%), malaria (1.93%), multiple myeloma (0.96%), Myelofibrosis (0.96%) and hypersplenism (0.96%) each and every case shows reactivity in bone marrow .these reactivity easily find out with the help of reticulocyte count. CONCLUSION- Reticulocyte is good clinical and hematological laboratory spectrum indicator of Pancytopenic –bone marrow disorder”.There was statistically no significant (p>0.05) difference of age groups of patients in the megaloblastic and non megaloblastic type of anemia groups. Keyword-Pancytopenia,megaloblastic anemia
Authors and Affiliations
Dr. Sachin sharma
Keywords
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