Retigabine – a new antiepileptic drug with a different mechanism of action
Journal Title: Advances in Hygiene and Experimental Medicine - Year 2013, Vol 67, Issue 0
Abstract
Retigabine belongs to a new generation of antiepileptic drugs. Its mechanism of action is different from that previously known. Retigabine opens potassium channels of subfamily Kv 7, especially Kv 7.2 and Kv 7.3. The drug enhances GABA-ergic transmission. It is well absorbed from the digestive system and undergoes metabolism via glucuronidation and acetylation. There is no interaction between retigabine and other antiepileptic drugs except lamotrigine. The drug has been registered as treatment of partial onset seizures with or without secondary generalization in adults. The efficacy of retigabine is being tested in other types of seizures and disorders characterized by neuronal hyperexcitability. Neuroprotective activity of retigabine is also being researched.
Authors and Affiliations
Ewa Zwierzyńska, Bogusława Pietrzak
Keywords
Related Articles
- EP ID EP67115
- DOI -
- Views 156
- Downloads 0
Antimicrobial peptides in asthma pathogenesis
Antimicrobial peptides exhibit activity against bacteria, viruses, fungi, and parasites. They have been described not only as endogenous antibiotics but also as immune modulators with an impact on innate and adaptive imm...
Długotrwałe spożywanie oleju rybnego może chronić mózg przed zmianami neurodegeneracyjnymi związanymi z wiekiem
Morfologiczne i molekularne podstawy rozwoju serca
Serce jest narządem pochodzenia mezodermalnego, którego rozwój regulowany jest przez wiele genów. Początkowo najważniejsze znaczenie ma ekspresja genów: Nkx2.5, CR1, pitx2, anf i mhc2a, które wpływają na różnicowanie kar...
Związek między osoczowymi stężeniami hormonów, stanem odżywienia i wydarzeniami stresogennymi u pacjentek z jadłowstrętem psychicznym
Enterobacteriaceae infection – diagnosis, antibiotic resistance and prevention
Intestinal infections caused by rod-shaped bacteria of the [i]Enterobacteriaceae[/i] genus are one of the major health hazards in countries where sanitation standards are low. [i]Strains[/i] of [i]Shigella,[/i] [i]Salm...