Retinol-binding protein-4
Journal Title: Journal of Analytical Bio-Science - Year 2011, Vol 34, Issue 5
Abstract
Retinol-binding protein (RBP) is one of the members of the lipocalin family, which binds and transports retinol (vitamin A). Recent studies revealed that RBP has several isoforms; cellular RBP-1, -2 and -3, and plasma RBP-4 (also traditionally known as ''RBP''). Cellular RBPs have a role in the intercellular transport of retinoids (i.e., retinol, retinal and retinoic acid). Plasma RBP-4 is synthesized mostly in liver, but little in adipose tissue (especially, in visceral fat). Because plasma RBP-4 of liver origin is measured as a marker of nutritional status and that of adipose tissue origin as a marker of insulin resistance, we overviewed the assay methods for both plasma RBPs of liver and adipose tissue origin, together with their plasma concentrations observed by each method.
Authors and Affiliations
Hiroshi Ihara
Keywords
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