Retrospective study of feto-maternal outcome in Hepatitis E infection in third trimester of pregnancy at a tertiary care hospital in Western India
Journal Title: Journal of the Indian Medical Association - Year 2018, Vol 116, Issue 12
Abstract
To study of Feto-Maternal outcome in Hepatitis E (HEV) infection in third trimester of pregnancy and to suggest measures for its prevention during pregnancy. After due permission, course of disease and feto-maternal outcome was studied from case papers of patients who were infected with Hepatitis E during third trimester of pregnancy. Analysis of data of 38 patients was done. Proportion of Hepatitis E in third trimester of pregnancy was 0.19%. Maximum numbers of patients 6(15.7%) were reported in months of September and November each. Maximum numbers of patients 23(60.5%) were in age group of 20 to 25 years. Majority 33(86.8%) patients were from lower socioeconomic class. Majority 32(84.2%) patients were emergency admissions. Serum bilirubin was more than 5mg/dl in 35(92.1%). Alkaline phosphatase and serum transaminases were raised in 30(79%) and 33(86.9%) respectively. Coagulation tests were altered in 24(63.1%) patients. Preterm normal deliveries were 21(67.7%) and 6(19.3%) were preterm Caesarean Section (CS). Low birth weight (LBW) was reported in 27(87%). Stillbirths were 7 (22.5%). Perinatal mortality was 11(35.4%). Out of all, 25(65.7%) patients had complications. Disseminated Intravascular Coagulation (DIC) was the most common complication encountered in 24(63.1%). Hepatic encephalopathy occurred in 11(28.9%). Blood components were given in 29(76.3%) of patients. Total 8(21%) patients died following fulminant hepatic failure (FHF), Disseminated Intravascular Coagulation (DIC) and Hepatic encephalopathy. Equal number of patients died in antenatal and postnatal period that, is 4 (10.5%) in each period. Hepatitis E infection in third trimester of pregnancy has a worsening course leading to high feto-maternal morbidity and mortality; hence prevention of Hepatitis E infection in pregnancy is very essential.
Authors and Affiliations
Rajal V Thaker, Parul T Shah
Keywords
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