Retrospective Study of Sickle Cell Disease in Tribal District of Maharashtra: Gondia
Journal Title: International Journal of Medical Science and Innovative Research (IJMSIR) - Year 2018, Vol 3, Issue 5
Abstract
Introduction: Sickle cell disease (SCD) is a genetic disorder of great epidemiological, clinical and public health relevance in developing countries like India. In Maharashtra, the prevalence of disease varies from 1.9% to 33.5% in different communities with an overall prevalence of 10%. This study was conducted to estimate the yield of HPLC in diagnosing Sickle cell disease on the basis of symptoms suggesting sickle cell disease in an endemic area of tribal district. Material and Methods: This retrospective record based study was conducted in a tertiary care institute in Gondia district of Maharashtra among 767 participants during the period from October 2009 to February 2015. Patients with the symptoms of sickle cell disease were enrolled for HPLC testing in clinical biochemistry laboratory. Results: Most of the cases were registered in 2011-12 year. The mean age of cases was 18.01±10.85 years with a range of 1-60 years. 5.35% of study subjects were affected in sickle cell disease while 4.43% of study subjects were sickle cell trait. Most of the Sickle cell disease cases were confirmed in males (61%) while most of the carrier was found in females (70.6%). Conclusion: The overall yield of sickle cell disease and carrier was found to be 9.78% with higher prevalence of sickle cell disease among males and sickle cell carrier among females. HPLC is best tool for screening of sickle cell disease for early diagnosis and prevention of complications amongst them.
Authors and Affiliations
Dr Ashok Jadhao
Keywords
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