Review on Tumour Microenvironment Cell Types Associated with Metastatic Cancer
Journal Title: Diseases & Research - Year 2023, Vol 3, Issue 2
Abstract
The Tumour microenvironment (TME) is a highly dynamic and perpetually altering entity of cancer development, progression, invasion, and dissemination. TME is interspersed with cellular components such as immune cells, blood vessels and stromal cells, and non-cellular components comprising extracellular matrix (ECM) and exosomes. Different cancer types possess distinct phenotypes of TME. The intricate processes of TME facilitate uncontrolled bulk formation, and chaotic vascularization, supporting oxygen and blood availability, along with the removal of metabolic wastes and aberrant metastatic colonization and seeding. Tumour masses are embedded with diverse innate and adaptive immune system cell milieu, capable of performing both pro and anti-tumorigenic effects. The nexus underpinning cancer cells and associated TME, such as cell-cell or cell-ECM interactions, play a key role in determining safe and effective therapeutic interventions. This review mainly emphasizes different roles of various cell types involved in the tumour microenvironment in the progression and promotion of metastatic potencies of tumour cells. We have further suggested that the targeting of all these cell types in the tumour microenvironment may give better cancer therapies in the near future.
Authors and Affiliations
Srirupa G. Choudhary, Pravin D. Potdar
Keywords
Related Articles
- EP ID EP740182
- DOI 10.54457/DR.202302001
- Views 23
- Downloads 0
Determination of mRNA Targets of miR-376c within the RNA-Induced Silencing Complex
Background The focus of the present study was to establish an easy combined method based on the MirTrap system together with a mRNA array to efficiently define target mRNAs which can be bound by miR-376 within the RNA-in...
A Commentary on the Natural Disease Progression Sequence of Chronic Hepatitis B
Hepatitis B virus (HBV), an ancient family of hepatotropic DNA viruses with origins dating back millions of years, remains a major burden to human health today, although hepatitis B vaccines have dramatically reduced the...
Efficacy of Platelet-Rich Plasma Combined with Wen Shen Formula in the Treatment of Thin Endometrium-Related Infertility
Objective To explore the effectiveness of Platelet-Rich Plasma (PRP) combined with Wen Shen Formula in treating thin endometrium. Methods From January 2019 to January 2023, 90 patients with thin endometrium-related infe...
Multiparameter Flow Cytometry: An Important Auxiliary Tool for The Diagnosis and Differential Diagnosis of Myelodysplastic Neoplasms
Multiparameter flow cytometry (MFC) shows promise in the diagnosis and differential diagnosis of myelodysplastic neoplasms (MDS). By identifying abnormal immunophenotypes of different cell lineages in bone marrow (BM) ce...
Incidence of Side Effects During Tenofovir Alafenamide Monotherapy in Patients with Chronic Hepatitis B
Objective Tenofovir alafenamide (TAF) is a new prodrug of tenofovir that is widely used in chronic hepatitis B (CHB) patients, and its side effects have rarely been reported. We aimed to evaluate the incidence of side ef...