Revisitation of an old antimalarial to combat Psoriatic Arthritis administering an antidote to Santonin to avoid xanthopsia or maculopathy
Journal Title: Nasza Dermatologia Online - Year 2018, Vol 9, Issue 3
Abstract
Background: The mechanism of action of antimalarials in the treatment of patients with rheumatoid arthritis is hitherto unknown but is thought to involve changes in antigen presentation or effects on the innate immune system. Material and Methods: Patient with psoriatic artritis after ineffective therapy of three kinds of NSAIDs was used following therapy: chloroquine: 250 mg/day for one entire year; -ibuprofene: 600 mg/day for one entire year; thiamine: 1.6 mg/day. Was analyzed of Disease Activity Score (Das28 using three parameters, excluding the self evaluation, because of the problem of the subjectivity according to the method heralded by Van der Heijde DMFM, van’t Hof MA, van Riel PLCM, van de Putte LBA. Results: At the beginning Das28 was 2.4 and at the end of the trial it was 1.00. Conclusions: The antidotes to santonine are limewater, chloral hydrate and thiamine. The antidotes Forecasts a novel re-introduction of this antimalarial in therapy against RA as it reveals a good improvement according to the Das28 method of evaluation of remission of complex symptoms of the same Reumatoid Arthritis.
Authors and Affiliations
Lorenzo Martini, Piotr Brzezinski
Keywords
Related Articles
- EP ID EP358822
- DOI 10.7241/ourd.20183.8
- Views 36
- Downloads 0
Granulomatous reaction following mantoux test: A rare complication
-
Rudolf Happle i dermatologiczne eponimy związane z jego imieniem
Giant Tuberculosis Verrucosa Cutis
A 38year old man had asymptomatic slowly progressive warty lesion on extensor surface of left elbow and arm for about 20 years. Examination revealed larger one sized of 16cm×15cm and smaller one about 8cm×5cm. Lesions we...
Ganglionar tuberculosis with skin involvement (scrofuloderma) in an inmmunocompetent patient. A case report
Tuberculosis (TB) infection is most prevalent in the world and its frequency continues to increase, being endemic in Paraguay. TB disease is defined by the presence of clinical symptoms and signs depending on the locatio...
Dermoscopy of apocrine hydrocystoma: A first case report
Apocrine hydrocystoma (AH) is a translucent, skin-colored to bluish dome shaped cyst on the face. AH mimics basal cell carcinoma (BCC), blue nevus, amelanotic melanoma requiring histopathological confirmation. Dermoscopy...