Risk of cervical cancer and squamous intraepithelial lesions according to human papillomavirus high-risk serotypes detected by qualitative real-time in vitro PCR
Journal Title: European Journal of Gynaecological Oncology - Year 2019, Vol 40, Issue 1
Abstract
Purpose of investigation: To establish the relationship between high-risk human papillomavirus (hrHPV) serotypes and the odds of developing cervical intraepithelial lesions. Material and Methods: Retrospective cohort study using altered cervical cytology results and hrHPV test obtained by PCR. Groups were divided according to low-grade squamous intraepithelial lesions (LSIL), high-grade squamous intraepithelial lesions (HSIL) and squamous cervical cancer (SCC) results, while hrHPV was divided according to polymerase chain reaction (PCR) results in “other HR-HPV, HPV-16, and HPV-18. Logistic regression analysis was performed to estimate the odds of each hrHPV serotype in developing squamous intraepithelial lesions or SCC. Results: A total of 252 samples were analysed, mean age was 42 ± 12.65 years. Prevalence of hrHPV infection was 60% (n=152). “Other HR-HPV” group was the most common infection in our population (39%); nonetheless, there were no increased odds for any HPV group and the risk for developing LSIL. The odds for HSIL were 4.58 and 7 for “other HR-HPV” and HPV-16, respectively. Odds for SCC were 11.29 and 7.35 for HPV-18 and HPV-16. There were no significant odds in HPV-18 for HSIL and “other HR-HPV” SCC. Conclusion: The present authors found a greater prevalence for “other HR-HPV” group in this population. Nonetheless, HPV-16 and HPV-18 contribute the highest probability of developing HSIL and SCC.
Authors and Affiliations
R. J. Martinez-Portilla, M. Rial-Crestelo, M. A. Mejia-Ugarte, J. L. Lopez-Velazquez
Keywords
Related Articles
- EP ID EP626298
- DOI 10.12892/ejgo4270.2019
- Views 58
- Downloads 0
The role of erythropoietin and erythropoietin receptor expression in breast cancer
Erythropoietin (EPO) plays a number of important functions in the body. Contrary to original beliefs, its activity is not limited to exerting effects on cells along the erythropoietic pathway. Newly published results con...
Taraxacum officinale extract induces antitumorigenic effects in ovarian carcinoma cell lines
Purpose of Investigation: Patients suffering from ovarian cancer often use mistletoe preparations in combination with Taraxacum officinale (dandelion) extracts as supplementary therapy to conventional medicine. However,...
Immunohistochemical analysis of IQGAP2 in ovarian cancer
IQ motif-containing GTPase-activating protein 2 (IQGAP2) was regarded as a tumor suppressor in some cancers, but its expression pattern in various histological subtypes of ovarian cancer has not been investigated. Immuno...
Plasma fibrinogen, CRP, and hs-CRP levels in patients with benign and borderline ovarian tumours
Objective: Ovarian tumours can be classified as benign, borderline or malignant lesions. The purpose of this study was to assess, inter alia, fibrinogen concentration, and the (C-reactive proteins) and high-sensitivity C...
Surgical management of recurrent gynecological cancer: Complete resection is the key to longer survival
Summary Purpose of investigation: This study was conducted to elucidate the efficacy and feasibility of surgical management of recurrent gynecological (cervical, endometrial, and ovarian) cancers. Materials and Methods:...