RIVAROXABAN BEYOND INHIBITING THROMBOSIS: TARGETING INFLAMMATION AND ATHEROSCLEROSIS
Journal Title: European Journal of Biomedical and Pharmaceutical Sciences - Year 2019, Vol 6, Issue 8
Abstract
Recent evidence has described beneficial clinical effects among patients with stable coronary artery disease (CAD), peripheral artery disease (PAD), and/or stroke when low-dose rivaroxaban (anti-factor Xa) was added to aspirin. A decrease on atherothrombotic events was observed, in part, by optimization of vascular protection. While the function of platelets is well recognized, substantiation is being composed on the role of coagulation factors to the developments of both atherosclerosis and atherothrombosis. Coagulation factors participate importantly on thrombus formation, meaning fibrin materialization and platelet activation and aggregation. In addition, these factors facilitate numerous pathophysiologic mechanisms through activation of protease‐activated‐receptors (PARs). Consequently, the association of anticoagulant to antiplatelet has obtained interest in secondary prevention for CAD/PAD as residual atherothrombotic risks are reduced. In this review, based on these recent findings, we emphasize the importance of factor Xa inhibition on protease-activated receptor (PAR) inactivation. PARs participate markedly on the pathophysiology of atherothrombosis.
Authors and Affiliations
Dr. Carlos V. Serrano
Keywords
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