РОЛЬ ІНГІБІТОРА АКТИВАТОРА ПЛАЗМІНОГЕНА 1 ТИПУ У РОЗВИТКУ ЕНДОТЕЛІАЛЬНОЇ ДИСФУНКЦІЇ У ХВОРИХ НА ГОСТРИЙ ІНФАРКТ МІОКАРДА І ЦУКРОВИЙ ДІАБЕТ 2 ТИПУ
Journal Title: INTERNATIONAL ACADEMY JOURNAL "Web of Scholar" - Year 2018, Vol 2, Issue 2
Abstract
Background. The role of plasminogen activator ingibitor type 1 (PAI-1) in patients with acute myocardial infarction (AMI) and diabetes mellitus (DM) type 2 remains an understudied area. The aim of research is the assessment of plasminogen activator ingibitor type 1 and its links with carbohydrate, lipid metabolism parameters, coagulative system parameters in patients with acute myocardial infarction and type 2 diabetes mellitus following determination of plasma levels of plasminogen activator ingibitor type 1 and endothelial synthase (NOS). Materials and methods. The study involved examination of 73 patients with AMI and DM type 2, 57 patients with AMI and without DM type 2 and 20 substantially healthy subjects. The content of PAI-1 was established by enzyme-immunoassay using the commercial test system of Technoclone PAI-1 ELISA Kit (Austria). The content of NO synthase was established by enzyme-immunoassay using the commercial test system of Bender MedSystem (Austria). Carbohydrate and lipid parameters were determined by standard biochemical method. Results and discussion. The study provided a possibility to determine a direct correlation between PAI-1 and total cholesterol (r=0.72, p<0.05); LDL cholesterol (r=0.49, p<0.05), HDL cholesterol (r=-0.57, p<0.05), triglycerids (r=0.39, p<0.05), glucose (r=0.73, p<0.05), insulin (r=0.83, p<0.05), glycosylated hemoglobin (r=0.65, p<0.05), fibrinogen (r=0.35, p<0.05), prothrombin by Quique (r=0.84, p<0.05). Correlation analysis showed a reverse relationship between the level of PAI-1 and NO synthase (r=-0.79, p<0.05), a direct relationship between the level of PAI-1and C-reactive protein (r=0.93, p<0.05)
Authors and Affiliations
Д. В. Мінухіна, В. Д. Бабаджан, П. Г. Кравчун, В. В. Мінухін, В. А. Гаврилюк
Keywords
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