Role and mechanism of mast cells in solid tumors
Journal Title: Chinese Journal of Clinical Research - Year 2024, Vol 37, Issue 1
Abstract
Mast cells are a type of innate immune cells, and have long been considered to be related to the pathogenesis of allergic and autoimmune diseases. However, in recent years, a number of studies have found that mast cells play an indispensable role in tumor development, metastasis, infiltration and angiogenesis, providing new ideas for tumor diagnosis and immunotherapy. Once mast cells have infiltrated solid tumors, they are known as tumor-associated mast cells (TAMCs) and are one of the most controversial immune cells in tumor tissues with remarkable heterogeneity. In view of the important role of mast cells in inflammation and the immune system, this paper reviews the mechanisms of mast cells in solid tumor development and their relationship with angiogenesis and lymphangiogenesis, aiming to deepen the understanding of the relationship between mast cells and tumors.
Authors and Affiliations
LUO Yang*, ZHANG Qing, ZHANG Shu, ZHANG Jianguo, LIU Yifei
Keywords
Related Articles
- EP ID EP735794
- DOI 10.13429/j.cnki.cjcr.2024.01.002
- Views 30
- Downloads 0
Efficacy and safety of filiform needle combined with modified Zilan decoction for treatment of verruca plana among adolescents
Objective To evaluate the clinical efficacy and safety of filiform needles combined with modified Zilan decoction in treating verruca plana in adolescents. Methods A total of 120 adolescents with verruca plana treated at...
Study on the protective effect and mechanism of paeonol on myocarditis in sepsis mice
Objective To investigate the protective and anti-inflammatory effects of paeonol (PAE) on lipopolysaccharide (LPS) -induced myocarditis in septic mice. Methods A total of 30 male C57/bl-6 mice were randomly divided int...
Predictive indicators of acute kidney injury caused by exertional rhabdomyolysis
Objective To investigate the characteristics of exertional rhabdomyolysis (ERB) and the predictive value of creatine kinase (CK), myoglobin/creatine kinase (Mb/CK) ratio and other indicators for ERB patients with acute r...
Safety and feasibility analysis of indocyanine green guided preservation of upper rectal vessels in laparoscopic radical resection of sigmoid cancer
Objective To investigate the safety and feasibility of indocyanine green guided preservation of the superior rectal artery in patients undergoing laparoscopic radical resection for sigmoid cancer. Methods A total of 73 p...
Efficacy and prognosis of transurethral holmium laser en-blocresection of bladder tumor in the treatment of non-invasive bladder cancer
Objective To investigate the efficacy and prognosis of transurethral holmium laser en-bloc resection of bladder tumor (HOLRBT) and transurethral resection of bladder tumor (TURBT) in the treatment of non-invasive bladder...