Role of 2D echo in neonates with perinatal asphyxia and its correlation with cardiac troponin T levels and creatine kinase MB
Journal Title: IP International Journal of Medical Paediatrics and Oncology - Year 2017, Vol 3, Issue 2
Abstract
Objectives: To evaluate myocardial function in neonates with perinatal asphyxia by 2D Echo and cardiac Troponin T levels and creatine kinase MB. Methods: 30 term babies with perinatal asphyxia were selected as cases. They were evaluated within 48 hours of birth using clinical echocardiography and cardiac enzymes i.e. Troponin -T and CK-MB levels. Results: Incidence of cardiac dysfunction in neonates were reported and correlated with cardiac Troponin T levels and creatine phosphokinase MB- levels. In this study overall, 30% cases were reported with cardiogenic shock and cardiovascular dysfunction. 20% cases had clinical evidence of murmur. 16.6% cases had cardiac failure and 3.3% cases were asymptomatic. Cardiac enzymes were significantly increased in babies with perinatal asphyxia. Cardiac Troponin t levels ranges from 0.15- >=0.3ng/ml. CPK-MB levels ranged from 200±110 IU/L in this study. Tricuspid regurgitation seen in 6.7% cases. RV hypokinesia (67% cases) >LV hypokinesia (33.3%) cases. Incidence of cardiac changes and mortality increases with increasing levels of Troponin T.Mortality was seen in 2 out of 30 cases. The mean Troponin -T level in cases with cardiac dysfunction was 0.3ng/ml as compared to without cardiac dysfunction (<=0.1ng/ml). Cardiac Troponin T had higher sensitivity and specificity compared to CK-MB levels. Cardiac Troponin -t levels correlated well with severity and outcome in babies with perinatal asphyxia. Conclusion: Echocardiography and cardiac enzymes i.e. cardiac troponin T levels and CK-MB levels correlates well with severity and outcome in perinatal asphyxia.
Authors and Affiliations
Divya Mathur, Pradeep Kumar Gupta, Ajay Punj
Keywords
Related Articles
- EP ID EP300751
- DOI 10.18231/2455-6793.2017.0018
- Views 110
- Downloads 0
Study on dietary pattern and physical activity before diagnosis of cancer in cancer patients of a teaching hospital of Jharkhand: A pilot study
Introduction Cancer is among the leading causes of death worldwide It poses a major threat to public health worldwide and incidence has increased in most countries since 1990 The study aims to find any association betwee...
Diphtheria in Children- Are we even close to control the menace?
Introduction: Despite the success of mass immunization in many countries worldwide, diphtheria continues to play a major role as a lethal resurgent infectious disease. The case reports of resurgence/persistence of diphth...
Evaluation of short stature in paediatric age group in rural medical college
Introduction Short stature is defined as height below 3rd centile or less than two standard deviations SDs below the median height for that age and sex according to the population standard Approximately 3 children in any...
Role of 2D echo in neonates with perinatal asphyxia and its correlation with cardiac troponin T levels and creatine kinase MB
Objectives: To evaluate myocardial function in neonates with perinatal asphyxia by 2D Echo and cardiac Troponin T levels and creatine kinase MB. Methods: 30 term babies with perinatal asphyxia were selected as cases. The...
Incidence of early onset hypocalcaemia in newborns admitted in level III NICU
Background: Metabolic derangements like hypoglycaemia, hypocalcaemia, hyponatremia are common in newborns especially at risk babies like immature babies, infants of diabetic mother (IDM), babies with perinatal asphyxia1-...