Role of αB Crystallin on Serum Amyloid A Fibrils with Systemic Amyloidotic Mice Liver
Journal Title: Journal of Medical Science And clinical Research - Year 2015, Vol 3, Issue 7
Abstract
AlphaB-Crystallin is one of the heat shock proteins and its Chaperonic activity is well established. alphaBCrystallin forms complexes with denaturing proteins thereby preventing their uncontrolled aggregation. Chaperonine process has been shown to follow a saturation type of complexing, when the ability of the available alphaB-Crystallin to bind the target protein is exceeded, the excess target protein aggregates and eventually precipitates out of solution. The effect of alphaB-Crystallin on SAA fibril formation under systemic amyloidodsis in the liver, we have determined they interact with each other. In the present study, in-vitro and in-vivo studies on the role of the interaction of SAA/SAA fibrils with chaperones were investigated by congo red stain, immune fluorescence and radio labeling methods. The results indicated that there was SAA deposits in liver, increases the SAA level in the liver and the alphaB-Crystallin could liver SAA level comes near to control. In conclusion that the implication of SAA in the liver. The significance in-vivo study has shown B-Crystallin as a therapeutic use for SAA amyloid disease
Authors and Affiliations
Asokan C
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