Role of adipokines in obstructive sleep apnea syndrome
Journal Title: Polski Przegląd Otorynolaryngologiczny - Year 2015, Vol 4, Issue 2
Abstract
Obstructive sleep apnea syndrome (OSAS) is a sleep disorder characterized by repetitive episodes of apnea/hypopnea due to ventilatory limitation or arrest. A number of risk factors of OSAS were identifid, with obesity being one of the most principal ones. However, the reason why sleep apnea episodes occur in so many obese patients remains unknown. The limited literature data available suggest a possibility of increased secretion of certain adipokines such as leptin or apelin within the adipose tissue in response to hypoxia. Literature includes a number of reports on the role of individual adipokines in OSAS. However, no article has been published to date to summarize the results of these studies. This article discusses the results of studies on the role of leptin, apelin, omentin, obestatin, ghrelin, resistin and visfatin in OSAS. Particular attention was paid to studies assessing diurnal profies of adipokine secretion and the effects of continuous positive air pressure (CPAP) treatment on the changes in adipokine plasma levels were described. The analysis of studies conducted to date prevents unambiguous assessment of whether the change in the plasma levels of individual adipokines is a direct consequence of hypoxia due to OSAS or rather of the activity of the adipose tissue being excessively developed in most OSAS patients.
Authors and Affiliations
Maryla Śmietanowska, Jarosław Balcerzak, Agnieszka Cudnoch-Jędrzejewska, Kazimierz Niemczyk
Keywords
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