Role of Adiponectin and Pro-Inflammatory Cytokines in Ischemic Heart Disease
Journal Title: International Journal of Medical Research Professionals - Year 2018, Vol 4, Issue 5
Abstract
Aims & Objectives: Recent studies have shown adiponectin to be an anti-inflammatory adipokine having insulin sensitising properties. It is seen that Insulin resistance and inflammation contributes significantly to atherosclerosis. In our study, we estimated the levels of adiponectin and proinflammatory cytokines in patients with angiographically proven ischemic heart disease. Materials And Methods: 50 cases of angiographically proven ischemic heart disease and 50 age and sex matched controls with no evidence of ischemic heart disease on angiography were selected from GB Pant Hospital. Serum adiponectin, TNF-α and IL-6 levels were estimated by ELISA kit in both cases and controls. Results: The mean serum adiponectin level was lower in cases (5.97±0.80 μg/ml) as compared to controls (6.60±0.4 μg/ml).The mean serum levels of TNF-α were higher in cases as compared to controls and the p value was significant. IL-6 was also elevated significantly in cases as compared to controls. p value of <0.05 was regarded as statistically significant. Conclusion: Lower adiponectin levels in cases as compared to controls is suggestive of its role in reducing inflammation and insulin resistance in the etiopathogenesis of ischemic heart disease. Higher levels of pro-inflammatory cytokines in cases indicate that ischaemic heart disease is an inflammatory condition where glucose metabolism is deranged predisposing to atherosclerosis.
Authors and Affiliations
Arpita Suri, Ritu Singh, Sanjay Tyagi, Jayashree Bhattacharjee
Keywords
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- EP ID EP536659
- DOI 10.21276/ijmrp.2018.4.5.008
- Views 73
- Downloads 0
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