Role of Biomarkers ALCAM and CA-15-3 in the Diagnosis of Breast Cancer: A Case - Control Study
Journal Title: International Journal of Contemporary Medical Research - Year 2017, Vol 4, Issue 8
Abstract
Introduction: Biomarkers can serve as an easy and noninvasive method for the diagnosis of breast cancer. They can also be useful in grading and follow-up of these patients. The present study was done to compare the levels of serum Activated leukocyte cell adhesion molecule (ALCAM), carbohydrate antigen 15-3 (CA15-3) and salivary CA-15-3 in breast cancer patients and healthy controls and to correlate the levels of these biomarkers with histological grade and nuclear morphometry of breast cancer patients. Material and methods: This was case control study done at a tertiary care centre from November 2014 to June 2016. Newly diagnosed patients with a biopsy proven diagnosis of breast cancer and age matched healthy controls were included in the study. The serum levels of ALCAM and serum and salivary CA15-3 were determined by Sandwich Enzyme Linked Immunosorbent Assay (ELISA) with standard protocol. Human ALCAM (Qayee Bio) and the Calbiotech CA15-3 ELISA Kit were used for performing the ELISA. SPSS version 16.0 (Chicago, IL) was used for this purpose. Chi-square or fisher exact was used to compare qualitative variables. Mann- Whitney U test/ Kruskal-Wallis test were used to compare continuous variables as applicable. Results: The levels of biomarkers serum ALCAM (P<0.001), CA-15-3 (P<0.001) and salivary ALCAM (P<0.001) were significantly higher in the breast cancer patients as compared to the healthy controls. The receiver operation characteristic (ROC) curve showed that these biomarkers have a good accuracy in the diagnosis of the breast cancer. There was a significant positive association between grade of the disease and serum ALCAM levels (P=0.005) Conclusion: These serum and salivary biomarkers may be useful in the diagnosis of breast cancer. These biomarkers especially serum ALCAM can also predict disease severity. These findings needs to be replicated in larger population.
Authors and Affiliations
Nirupma Lal, Shoaib Irfan, Noorin Zaidi, Osman Musa, Aparna Mishra, Imran Rizvi
Keywords
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