Role of Brain-Derived Neurotrophic Factor on Cognition of Hypothyroid Neonatal Rats
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2014, Vol 2, Issue 6
Abstract
Mechanisms underlying the effects of inadequate thyroid hormone availability to the brain, on cognitive functions are not completely understood. The aim of this study is to assess if dysregulation of Brain derived neurotrophic factor (BDNF) through its gene methylation and / or brain oxidative stress state have a role .Fifteen female rats were divided into two groups; control and propylthiouracil hypothyroidism induced group. Offspring of each group were divided into three subgroups for assessment at 3, 7 days and 8 weeks. BDNF protein level, DNA methylation status of BDNF gene, malondialdehyde (MDA) and total antioxidant capacity (TAC) were measured in hippocampal brain tissue. Cognitive functions were assessed through Morris Water Maze (MWM) task to the subgroups of age 8 weeks. Results showed that BDNF protein level was significantly reduced in the hippocampi of maternal hypothyroidism offspring at the developmental stage (3 day and 7 day groups) (p value= <0.001in both groups), which was significantly associated with BDNF gene methylation state. Hippocampal MDA level was significantly increased in pups from hypothyroidism dams at the developmental stage (3 and 7 day groups) (p<0.001* in both groups). MWM task showed that 8 weeks-old maternal hypothyroidism offspring were significantly impaired in their performance (P<0.001) relative to age-matched controls. We conclude that, long-term memory deficits in hypothyroidism maybe caused by the interplay of the DNA methylation of BDNF gene, the excess oxidative stress and deteriorated antioxidant defense system in the brain hippocampus. Keywords: Hypothyroidism, Cognitive function, BDNF, Oxidative stress, Gene methylation
Authors and Affiliations
Radwa A Mehanna, Passainte H Saber, Doaa A Abdelmonsif, Rasha MA Nassra
Keywords
Related Articles
- EP ID EP376107
- DOI -
- Views 72
- Downloads 0
A Comparative Study of Radiological and Endoscopic Findings in Paranasal Sinus Disease
Abstract: The objective of the study was to elicit the importance of radiology and nasal endoscopy in the diagnosis of chronic rhinosinusitis and comparative study between nasal endoscopy and CT scan for diagnosis of par...
An Unusual Presentation of Gallbladder Carcinoma-Gallbladder Perforation and Anterior Abdominal Wall Abscess
Gallbladder perforation (GBP) is a rare but life threatening complication of acute cholecystitis with high morbidity and mortality rates because of delay in diagnosis. Most cases can only be diagnosed during surgery. Ni...
The formation of basilar artery and its significance
Abstract: Vertebro-basilar artery supplies the 20% of the blood supply of the brain. The formation of basilar artery is unique in our body system; it forms the important part in the posterior circulation. The aim of the...
Is a Five Marker Panel including Expression of Basal Markers (EGFR and/or CK5/6) compared to Three Marker Panel better in Predicting Prognosis in Molecular Subtypes of Breast Carcinoma?
Abstract: Breast cancer shows marked heterogeneity which is proven by the fact that tumors with similar morphologic and immunohisto-chemical features show distinct clinical behavior and different response to therapy. Thi...
Inflammatory Fibroid Polyp of Ileum: A Case Report
Abstract: Inflammatory fibroid polyps are benign tumors which arise from the submucosa of the stomach, small intestine, large intestine and oesophagus. They form polypoid lesion and present as intussusception or intestin...