ROLE OF C-REACTIVE PROTEIN IN SEVERITY ASSESSMENT AND MONITORING OF HOSPITALIZED PATIENTS WITH COMMUNITY-ACQUIRED PNEUMONIA
Journal Title: World Science - Year 2018, Vol 5, Issue 6
Abstract
Introduction. C-reactive protein (CRP) is one of the markers widely used in everyday clinical practice for monitoring of patients with infections. Aim. To evaluate the role of CRP in severity assessment and monitoring of hospitalized patients with community-acquired pneumonia (CAP). Material and Methods. 1292 patients hospitalized with CAP were retrospectively studied. CRP was measured on admission and on day 4-5. The severity of CAP was determined by PSI, IDSA/ATS criteria and CURB-65. Results. The mean CRP in non-survivors was significantly higher than in survivors (171.85±83.17mg/L vs. 123.42 ± 99.68mg/L, р<0.001). CRP increased significantly with increasing the severity group according to PSI, IDSA/ATS criteria and CURB-65, but the correlation coefficients were weak (r=0.21; r=0.26; r=0.23 resp., p<0.001). CRP≥200mg/L increased the risk of mortality (OR 2.74 (1.89-3.95) p<0.001). Patients with CRP decline <50 % on day 4-5 had significantly higher mortality rate, increased risk of complications and longer hospital stay. Conclusions. CRP is useful marker in monitoring patients with CAP. Both initial and control value can serve as predictors for severity and adverse outcome of CAP.
Authors and Affiliations
D. Miteva, Y. Radkov, V. Kostadinova
Keywords
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- EP ID EP331245
- DOI 10.31435/rsglobal_ws/12062018/5848
- Views 108
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