Role of Carbon Mono-Oxide (CO) Signaling During Trophoblast Invasion in Humans
Journal Title: Open Access Journal of Reproductive System and Sexual Disorders - Year 2019, Vol 2, Issue 2
Abstract
Trophoblast cells originating from the outer tropho ectodermal layer of the blastocyst forms the placenta, a transient organ that is instrumental in supporting pregnancy. The process begins with the interaction between two genetically dissimilar tissues, with the trophoblast cells, like a parasite programing the maternal system to suit its survival. A successful pregnancy is multistep process initiating with the process of proper orientation and apposition of the floating blastocyst to the maternal uterine endometrium. This is followed by the pseudo malignant trophoblasts invading the maternal decidua and securing an adequate supply of oxygen and nutrient to the fetus. Several cytokines and hormones are known to orchestrate this process derailment of which often have far reaching consequences. Carbon monoxide (CO) originating from HMOX (Heme Oxygenase) system is believed to play a crucial role in this process. Though not much is known about this system, preliminary findings from our lab points out an important role of this gaseous molecule during trophoblast invasion. Successful implantation is an outcome between two genetically dissimilar tissues that often depends on synchronization between the developmental stages of the embryo and the molecular events that are induced by paracrine and autocrine regulators [1]. The process of implantation begins six to seven days following fertilization [2,3] and consists basically of three stages [4]. Stage1: Apposition: It is the first stage denoting the initial, still unstable, adhesion of the blastocyst to the uterine wall. Micro protrusions from the apical uterine epithelium surface also known as Pino pods, inter-digitate with the microvilli on the apical surface of the multinucleated syncytiotrophoblast [5].
Authors and Affiliations
Subhradip Karmakar, Ruby Dhar, Indrani Mukherjee, Sunil Singh, Sandep Goswami
Keywords
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- EP ID EP648362
- DOI 10.32474/OAJRSD.2019.02.000133
- Views 86
- Downloads 0
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