ROLE OF CARBON SOURCE FOR THE PRODUCTION OF L-GLUTAMINASE FROM ASPERGILLUS ORYZAE
Journal Title: Journal of Drug Delivery and Therapeutics - Year 2014, Vol 4, Issue 5
Abstract
Microbial glutaminases are more stable than plant and animal counterparts. In addition to it, they have also been detected in mammalian tissues where they are the major enzymes responsible for catabolic breakdown of glutamine. This study were taken up to the enhance the biosynthesis of L-glutaminase by supplementation of carbon sources were employed in range of 0.25% to 1.0%. The carbon source were supplemented are glucose, fructose and lactose. In case of monosaccharides (fructose) the maximum L-glutaminase production of 494.1 IU was observed at 1% and where as disaccharides like lactose yielded maximum L-glutaminase of 343.5 IU.
Authors and Affiliations
Keywords
Related Articles
- EP ID EP497260
- DOI 10.22270/jddt.v4i5.983
- Views 73
- Downloads 0
PHARMACOLOGICAL STUDIES OF STAY-ON POWER CAPSULES IN RABBITS
The main objective of this study was to perform pharmacological evaluation of Stay-On Power Capsules in Rabbits (Non-Rodents) namely the aphrodisiac activity. The present investigation deals with Pharmacological Studies...
DEVELOPMENT AND EVALUATION OF PRONIOSOMES AS DRUG CARRIERS FOR TRANSDERMAL DELIVERY OF KETOROLAC TROMETHAMINE
Ketorolac tromethamine is a drug with narrow therapeutic index and short biological half-life. This study was aimed at developing and optimizing proniosomal formulation of ketorolac tromethamine in order to improve its b...
PLACEBO-CONTROLLED STUDY ON COMPARISON OF TWO HERBAL HYPOLIPIDEMIC AGENTS
Introduction: Hyperlipidemia, either primary or secondary causes atherogenetic abnormalities leading to coronary artery disease, cardiac arrest and arrhythmias. Herbal therapy for prevention or cure of Hyperlipidemia is...
Formulation and evaluation of polymeric nanoparticles of an antihypetensive drug for gastroretention
The aim of present study was to formulate and evaluate nanoparticles of carvedilol by using different hydrophilic polymers. Carvedilol was selected as a suitable drug for gastro- retentive nanoparticles due to its short...
SOLUBLITY ENHANCEMENT OF MICONAZOLE BY FORMULATION OF HYDROTROPIC SOLID DISPERSIONS
In the present research work mixed hydrotropic solubilization phenomenon is used to enhance the solubilization of poorly water-soluble drugs. Bulk drug samples were identified by the observed IR spectra and the melting p...