Role of Chlamydia pneumoniae in the pathogenesis of hypertrophy and adenoid tissue inflammation in children
Journal Title: Otolaryngologia Polska - Year 2016, Vol 70, Issue 5
Abstract
Objective. A tropism to epithelial cells and lymphocytes, an inhibition of apoptosis in host cells, an ability to occurrence in persistent form resistant to antibiotic treatment are the features of Chlamydia pneumoniae, which can have connection with chronic inflammation of an adenoid tissue and adenoid hypertrophy. This study aimed to (1) detect the C. pneumoniae in an adenoid in children undergoing adenoidectomy, (2) estimate a connection between C. pneumoniae occurrence and the size of adenoid, (3) demonstration in which of adenoid cells C. pneumoniae occurs most often. Material and methods. The examined group consisted of 200 children aged from 2 to 16 years (mean age 6,4) undergoing adenoidectomy. In all children during qualification for adenoidectomy a fiberoscopic examination of the nasopharynx was performed. A part of removed adenoid tissue was analysed by real-time PCR for C. pneumoniae. Adenoids from children with positive PCR examination and from 10 children with negative PCR examination were examined using immunohistochemistry (IHC). Results. C. pneumoniae in the adenoid was present in 5,5% children. Positive results were obtained most frequently (24,14%, 7/29) in the eldest group (10-16 years). A statistical analysis demonstrated the correlation between C. pneumoniae occurrence in an adenoid tissue and the size of adenoid. In immunohistochemistry C. pneumoniae was found the most frequently in lymphocytes and in epithelial cells. Conclusions. A presence of C. pneumoniae in lymphocytes and epithelial cells of the adenoid first of all in older children with adenoid hypertrophy confirms the participation of this bacteria in adenoid pathology.
Authors and Affiliations
Anna Bielicka, Beata Zielnik-Jurkiewicz, Edyta Podsiadły, Monika Prochorec-Sobieszek, Joanna Rogulska, Urszula Demkow
Keywords
Related Articles
- EP ID EP79037
- DOI 10.5604/00306657.1209437
- Views 73
- Downloads 0
Komunikat Komisji d.s. Członków Honorowych Polskiego Towarzystwa Otorynolaryngologów Chirurgów Głowy i Szyi
Powikłania tracheotomii przezskórnej – opis przypadku
Introduction: Tracheotomy is one of the most oldest operations in surgery. Percutaneous dilational tracheotomy has become increasingly popular as an alternative to standard tracheotomy over the last 30 years. It is parti...
Dysphagia after total laryngectomy
Reoperacje w otosklerozie
The authors present 68 cases of revision stapes surgery in otosclerosis. This review analyzed intraoperative findings and postrevision hearing results. According to our observations, the most common causes of failure aft...
Rola terapii fotodynamicznej w paliatywnym leczeniu nowotworów głowy i szyi
Wstęp: Nowotwory głowy i szyi stanowią około 6% wszystkich raków. Na świecie każdego roku są przyczyną około 650 tysięcy nowych zachorowań i około 260 tysięcy zgonów. Pomimo intensywnego skojarzonego leczenia u około 50%...