Role of HCV Infection in Psoriasis: A Clinical and Immunohistochemical Study
Journal Title: Journal of Clinical and Diagnostic Research - Year 2019, Vol 13, Issue 5
Abstract
ABSTRACT Introduction: Psoriasis is a common inflammatory skin disorder in which different infections play an important role in its pathogenesis. It was proposed that Hepatitis C Virus (HCV) is involved in psoriasis pathogenesis, and may contribute to its severity. This hypothesised role of HCV in psoriasis emerged through investigating serum HCV antibody and plasma HCV RNA levels, however till date, no study investigated HCV protein in skin of psoriasis patients. Aim: To investigate the role of HCV in aetiopathogenesis of psoriasis through evaluation of HCV protein immunohistochemical expression in lesional skin biopsies of HCV positive psoriatic patients compared to non-psoriatic patients and controls. Materials and Methods: Twenty HCV positive psoriatic patients (32-65 years) in addition to 20 age and sex matched HCV positive non-psoriatic patients (31-58 years) and 20 healthy control subjects (36-57 years) were included in this case-control study. Psoriasis Area Severity Index (PASI) score was used to evaluate psoriasis severity. Skin biopsies were taken from all groups and were stained with Haematoxylin and Eosin stain (H and E) and immunohistochemically by HCV protein monoclonal antibody. Results: HCV protein immunoreactivity was significantly decreased in HCV positive psoriatic patients than non-psoriatic patients (p=0.02), however, its percentage and H-score mean values were significantly elevated in psoriatic than non-psoriatic HCV positive cases (p=0.044 and p=0.03 respectively). HCV protein expression was positively associated with psoriasis severity (p=0.032) and its cutaneous load was positively associated with disease duration (p=0.05). Conclusion: Not the presence of HCV infection, but its cutaneous load may have an active role in pathogenesis of psoriasis. This cutaneous load was positively associated with disease duration. Moreover, HCV infection is associated with psoriasis severity.
Authors and Affiliations
Azza Gaber Antar Farag, Elsayed Ebrahim Elshayb, Dalia Rifaafaat Al Sharaky, Eman Nabil Elashafey, Amal Abd Elmonem Abo Khadra
Keywords
Related Articles
- EP ID EP583266
- DOI 10.7860/JCDR/2019/39627.12833
- Views 121
- Downloads 0
Comparison of Methods to Assay Liver Glycogen Fractions: The Effects of Starvation
Introduction: There are several methods to extract and measure glycogen in animal tissues. Glycogen is extracted with or without homogenization by using cold Perchloric Acid (PCA). Aim: Three procedures were compared to...
Changes in Gas Composition during Low Flow Anaesthesia without Nitrous Oxide
Introduction: Low flow anaesthesia utilising Oxygen (O2 ) and Nitrous Oxide (N2 O) mixture carries a risk of hypoxia, but avoiding N2 O results in increased analgesic and volatile anaesthetic agent requirement. Aim: This...
Prosthetic Joint Infection due to Burkholderia cenocepacia: An Opportunistic Pathogen Microbiology Section with an Expanding Spectrum of Disease
Burkholderia cenocepacia is an opportunistic pathogen widespread in moist environments. It has been associated with lung infections, blood, skin and genitourinary tract infections. We report here the first case of Prosth...
Hypolipidaemic Effects of Gymnema sylvestre on High Fat Diet Induced Dyslipidaemia in Wistar Rats
Introduction: Hyperlipidaemia is a well known risk factor for cardiovascular diseases. Lifestyle modification can be the initial step to reduce cholesterol levels. There are various drugs which are used to control dyslip...
Comparison of Efficacy of Low Dose (25 mg) with High Dose Diclofenac (50 mg) in Management of Postoperative Pain after Periodontal Flap Surgery: A Randomised Clinical Trial
ABSTRACT Introduction: The perception of pain is highly subjective and varies substantially among individuals. Diclofenac is powerful NSAID and is associated with adverse effect, like gastric irritability. Aim: To compar...